Endoplasmic reticulum stress and unfolded protein response in neurodegenerative diseases
The endoplasmic reticulum (ER) is an important organelle involved in protein quality control
and cellular homeostasis. The accumulation of unfolded proteins leads to an ER stress …
and cellular homeostasis. The accumulation of unfolded proteins leads to an ER stress …
The structure, activation and signaling of IRE1 and its role in determining cell fate
N Siwecka, W Rozpędek-Kamińska, A Wawrzynkiewicz… - Biomedicines, 2021 - mdpi.com
Inositol-requiring enzyme type 1 (IRE1) is a serine/threonine kinase acting as one of three
branches of the Unfolded Protein Response (UPR) signaling pathway, which is activated …
branches of the Unfolded Protein Response (UPR) signaling pathway, which is activated …
Living dangerously: protective and harmful ER stress responses in pancreatic β-cells
Type 2 diabetes (T2D) is a growing cause of poor health, psychosocial burden, and
economic costs worldwide. The pancreatic β-cell is a cornerstone of metabolic physiology …
economic costs worldwide. The pancreatic β-cell is a cornerstone of metabolic physiology …
Peptidomimetic‐based identification of FDA‐approved compounds inhibiting IRE1 activity
D Doultsinos, A Carlesso, C Chintha… - The FEBS …, 2021 - Wiley Online Library
Inositol‐requiring enzyme 1 (IRE1) is a bifunctional serine/threonine kinase and
endoribonuclease that is a major mediator of the unfolded protein response (UPR) during …
endoribonuclease that is a major mediator of the unfolded protein response (UPR) during …
Chronic obstructive pulmonary disease and emerging ER stress-related therapeutic targets
COPD pathogenesis is frequently associated with endoplasmic reticulum stress (ER stress)
progression. Targeting the major unfolded protein response (UPR) branches in the ER …
progression. Targeting the major unfolded protein response (UPR) branches in the ER …
The IRE1 inhibitor Kira6 curtails the inflammatory trait of immunogenic anticancer treatments by targeting Hsp60 independent Of IRE1
Cellular stress evoked by immunogenic anticancer treatments engaging the unfolded
protein response (UPR) can elicit inflammation with conflicting therapeutic outcomes. To …
protein response (UPR) can elicit inflammation with conflicting therapeutic outcomes. To …
Endoplasmic Reticulum Stress and Emerging Therapeutic Targets in Cancer
Endoplasmic reticulum stress (ER stress) is characterized by the accumulation of misfolded
and unfolded proteins in the ER lumen. To mitigate the imbalanced ER protein-folding …
and unfolded proteins in the ER lumen. To mitigate the imbalanced ER protein-folding …
Unfolded Protein Response Activation Enhances Lung Endothelial Barrier Function
KT Kubra - 2023 - search.proquest.com
The unfolded protein response (UPR) is a homeostatic feedback mechanism that enables
the cells to control endoplasmic reticulum (ER) stress. UPR restores proteostasis by …
the cells to control endoplasmic reticulum (ER) stress. UPR restores proteostasis by …
[BOOK][B] Exploring NADPH levels during ER stress using novel homoFRET sensors
A Bennett - 2020 - search.proquest.com
In beta-cells, insulin misfolding occurs at rates as high as 20%. Misfolded insulin aggregates
lead to endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). The …
lead to endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). The …
Characterisation of the unfolded protein response in prostate cancer, and investigation of the ATF6 interactome using a modified mammalian expression system.
AM Isac - 2022 - repository.essex.ac.uk
Prostate cancer (PCa) cells grow in an environment which is known to cause endoplasmic
reticulum (ER) stress. This activates a process called the unfolded protein response (UPR) …
reticulum (ER) stress. This activates a process called the unfolded protein response (UPR) …