Epigenetic mechanisms for controlling gene expression through heritable modifications to
DNA, RNA, and proteins, are essential processes in maintaining cellular homeostasis. As a …

Bromodomains are protein modules that bind to acetylated lysine residues. Their interaction
with histone proteins suggests that they function as “readers” of histone lysine acetylation, a …

Th17 responses are critical to a variety of human autoimmune diseases, and therapeutic
targeting with monoclonal antibodies against IL-17 and IL-23 has shown considerable …

The SWI/SNF multisubunit complex modulates chromatin structure through the activity of two
mutually exclusive catalytic subunits, SMARCA2 and SMARCA4, which both contain a …

Components of the chromatin remodelling switch/sucrose nonfermentable (SWI/SNF)
complex are recurrently mutated in tumors, suggesting that altering the activity of the …

The histone acetyltransferases CBP/p300 are involved in recurrent leukemia-associated
chromosomal translocations and are key regulators of cell growth. Therefore, efforts to …

The bromodomain‐containing proteins BRD9 and BRD7 are part of the human SWI/SNF
chromatin‐remodeling complexes BAF and PBAF. To date, no selective inhibitor for BRD7/9 …

Bromodomains, small protein modules that recognize acetylated lysine on histones, play a
significant role in the epigenome, where they function as “readers” that ultimately determine …

Proteins of the bromodomain and extraterminal (BET) family, in particular bromodomain-
containing protein 4 (BRD4), are of great interest as biological targets. BET proteins contain …

Mammalian SWI/SNF [also called Brg/Brahma-associated factors (BAFs)] are evolutionarily
conserved chromatin-remodeling complexes regulating gene transcription programs during …