[PDF][PDF] Chromaffin cells of the adrenal medulla: physiology, pharmacology, and disease
Chromaffin cells (CCs) of the adrenal gland and the sympathetic nervous system produce
the catecholamines (epinephrine and norepinephrine; EPI and NE) needed to coordinate …
the catecholamines (epinephrine and norepinephrine; EPI and NE) needed to coordinate …
Cav1. 2 channelopathies causing autism: new hallmarks on Timothy syndrome
A Marcantoni, C Calorio, E Hidisoglu… - … -European Journal of …, 2020 - Springer
Abstract Cav1. 2 L-type calcium channels play key roles in long-term synaptic plasticity,
sensory transduction, muscle contraction, and hormone release. De novo mutations in the …
sensory transduction, muscle contraction, and hormone release. De novo mutations in the …
Loss of Cav1. 3 channels reveals the critical role of L-type and BK channel coupling in pacemaking mouse adrenal chromaffin cells
We studied wild-type (WT) and Cav1. 3−/− mouse chromaffin cells (MCCs) with the aim to
determine the isoform of L-type Ca2+ channel (LTCC) and BK channels that underlie the …
determine the isoform of L-type Ca2+ channel (LTCC) and BK channels that underlie the …
Cav1.3 and BK Channels for Timing and Regulating Cell Firing
Abstract L-type Ca 2+ channels (LTCCs, Ca v 1) open readily during membrane
depolarization and allow Ca 2+ to enter the cell. In this way, LTCCs regulate cell excitability …
depolarization and allow Ca 2+ to enter the cell. In this way, LTCCs regulate cell excitability …
Pharmacological implications of the Ca2+/cAMP signaling interaction: from risk for antihypertensive therapy to potential beneficial for neurological and psychiatric …
A Caricati‐Neto, AG García… - Pharmacology Research …, 2015 - Wiley Online Library
In this review, we discussed pharmacological implications of the Ca2+/cAMP signaling
interaction in the antihypertensive and neurological/psychiatric disorders therapies. Since …
interaction in the antihypertensive and neurological/psychiatric disorders therapies. Since …
Early alterations of hippocampal neuronal firing induced by Abeta42
D Gavello, C Calorio, C Franchino, F Cesano… - Cerebral …, 2018 - academic.oup.com
We studied the effect of Amyloid β 1-42 oligomers (Abeta42) on Ca2+ dependent excitability
profile of hippocampal neurons. Abeta42 is one of the Amyloid beta peptides produced by …
profile of hippocampal neurons. Abeta42 is one of the Amyloid beta peptides produced by …
T-type channel-mediated neurotransmitter release
E Carbone, C Calorio, DHF Vandael - Pflügers Archiv-European Journal …, 2014 - Springer
Besides controlling a wide variety of cell functions, T-type channels have been shown to
regulate neurotransmitter release in peripheral and central synapses and neuroendocrine …
regulate neurotransmitter release in peripheral and central synapses and neuroendocrine …
Bud extracts from Tilia tomentosa Moench inhibit hippocampal neuronal firing through GABAA and benzodiazepine receptors activation
A Allio, C Calorio, C Franchino, D Gavello… - Journal of …, 2015 - Elsevier
Abstract Ethnopharmacological relevance Tilia tomentosa Moench bud extracts (TTBEs) is
used in traditional medicine for centuries as sedative compound. Different plants belonging …
used in traditional medicine for centuries as sedative compound. Different plants belonging …
Cav1. 3-driven SK channel activation regulates pacemaking and spike frequency adaptation in mouse chromaffin cells
DHF Vandael, A Zuccotti, J Striessnig… - Journal of …, 2012 - Soc Neuroscience
Mouse chromaffin cells (MCCs) fire spontaneous action potentials (APs) at rest. Cav1. 3 L-
type calcium channels sustain the pacemaker current, and their loss results in depolarized …
type calcium channels sustain the pacemaker current, and their loss results in depolarized …
Impaired chromaffin cell excitability and exocytosis in autistic Timothy syndrome TS2‐neo mouse rescued by L‐type calcium channel blockers
C Calorio, D Gavello, L Guarina, C Salio… - The Journal of …, 2019 - Wiley Online Library
Key points Tymothy syndrome (TS) is a multisystem disorder featuring cardiac arrhythmias,
autism and adrenal gland dysfunction that originates from a de novo point mutation in the …
autism and adrenal gland dysfunction that originates from a de novo point mutation in the …