Clonal hematopoiesis (CH) defines a premalignant state predominantly found in older
persons that increases the risk of develo** hematologic malignancies and age-related …

Skeletal muscle aging is a key contributor to age-related frailty and sarcopenia with
substantial implications for global health. Here we profiled 90,902 single cells and 92,259 …

Osteogenic differentiation is crucial in normal bone formation and pathological calcification,
such as calcific aortic valve disease (CAVD). Understanding the proteomic and …

Altered cell-cell communication is a hallmark of aging, but its impact on bone marrow aging
remains poorly understood. Based on a common and effective pipeline and single-cell …

The immune system comprises multiple cell lineages and heterogeneous subsets found in
blood and tissues throughout the body. While human immune responses differ between …

Bone is a multifaceted tissue requiring orchestrated interplays of diverse cells within
specialized microenvironments. Although significant progress has been made in …

Single-cell RNA sequencing (scRNA-seq) has emerged as the key technique for studying
transcriptomics at the single-cell level. In our previous work, we presented the DISCO …

Osteomyelitis occurs when Staphylococcus aureus invades the bone microenvironment,
resulting in a bone marrow abscess with a spatially defined architecture of cells and …

Philadelphia chromosome-like B-cell acute lymphoblastic leukemia (Ph-like ALL) is driven
by genetic alterations that induce constitutive kinase signaling and is associated with …

The development and maturation of B lymphocytes involve intricate orchestrated processes,
where dedicated gene regulations (GR) take place within specific microenvironments …