The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …

Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

In recent years, it has become evident that the volume of a given cell is an important factor
not only in defining its intracellular osmolality and its shape, but also in defining other …

This review describes recent progress concerning the molecular aspects of the Na+/H+
exchanger. The Na+/H+ exchanger is an important regulator for intracellular pH, cell volume …

The Na+-H+ exchange (NHE) is a major mechanism by which the heart adapts to
intracellular acidosis during ischemia and recovers from the acidosis after reperfusion …

Maintaining intracellular pH values close to neutrality is a crucial task for a wide variety of
cells. Hence, various mechanisms for pH regulation have been selected early in evolution …

NHE3 is the brush-border (BB) Na+/H+ exchanger of small intestine, colon, and renal
proximal tubule which is involved in large amounts of neutral Na+ absorption. NHE3 is a …

Lysosomes serve as cellular degradation and signalling centres that coordinate metabolism
in response to intracellular cues and extracellular signals. Lysosomal capacity is adapted to …

Apoptosis results in cell shrinkage and intracellular acidification, processes opposed by the
ubiquitously expressed NHE1 Na+/H+ exchanger. In addition to mediating Na+/H+ transport …

Sodium/proton exchangers [Na+/H+ (NHEs)] play an important role in salt and water
absorption from the intestinal tract. To investigate the contribution of the apical membrane …