Tumor necrosis factor-α (TNF-α) plays an essential role in the regulation of bone
homeostasis in several chronic immune and inflammatory joint diseases, where inhibition of …

The strength and integrity of our bones depends on maintaining a delicate balance between
bone resorption by osteoclasts and bone formation by osteoblasts. As we age or as a result …

Osteoclasts and osteoblasts dictate skeletal mass, structure, and strength via their respective
roles in resorbing and forming bone. Bone remodeling is a spatially coordinated lifelong …

The past decade has seen an explosion in the field of bone biology. The area of bone
biology over this period of time has been marked by a number of key discoveries that have …

In the present study, we examined the expression of regulators of bone formation and
osteoclastogenesis in human atherosclerosis because accumulating evidence suggests that …

Receptor activator of nuclear factor (NF-κB) ligand (RANKL), its cellular receptor, receptor
activator of NF-κB (RANK), and the decoy receptor osteoprotegerin (OPG) constitute a novel …

There is considerable evidence that osteoclasts are involved in the pathogenesis of focal
bone erosion in rheumatoid arthritis. Tumor necrosis factor-related activation-induced …

The detailed cellular and molecular mechanisms leading to joint destruction in rheumatoid
arthritis, a disease driven by proinflammatory cytokines, are still unknown. To address the …

Bone loss represents a major unsolved problem in rheumatoid arthritis (RA). The skeletal
complications of RA consist of focal bone erosions and periarticular osteoporosis at sites of …

Rheumatoid arthritis, juvenile idiopathic arthritis, the seronegative spondyloarthropathies
including psoriatic arthritis, and systemic lupus erythematosus are all examples of rheumatic …