Eukaryotic proteomes are enormously sophisticated through versatile post-translational
modifications (PTMs) of proteins. A large variety of code generated via PTMs of proteins by …

Interferons (IFNs) are a broad class of cytokines that have multifaceted roles. Type I IFNs
have variable effects when it comes to host susceptibility to bacterial infections, that is, the …

Excessive type I interferon (IFNα/β) activity is implicated in a spectrum of human disease, yet
its direct role remains to be conclusively proven. We investigated two siblings with severe …

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a
global pandemic of severe coronavirus disease 2019 (COVID-19). Staphylococcus aureus is …

Dengue virus (DENV) infection remains a challenging health threat worldwide. Ubiquitin-
specific protease 18 (USP18), which preserves the anti-interferon (IFN) effect, is an ideal …

Aberrant activation of epithelial-mesenchymal transition (EMT) pathway drives the invasion
and migration of multiple cancers including glioblastoma (GBM). Clinical interventions …

Background Spinal cord ischemia–reperfusion injury (SCII) is usually caused by spinal
surgery, often leading to severe neurological deficits. The ubiquitin-specific protease 18 …

The early detection of bacterial pathogens through immune sensors is an essential step in
innate immunity. STING (Stimulator of Interferon Genes) has emerged as a key mediator of …

Background A major issue with the current management of psoriasis is our inability to predict
treatment response. Objective Our aim was to evaluate the ability to use baseline molecular …

Macrophage metabolic plasticity is central to inflammatory programming, yet mechanisms of
coordinating metabolic and inflammatory programs during infection are poorly defined …