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Recent advances in the monitoring, modelling and control of crystallization systems
Crystallization is one of the most important unit operations used for the separation and
purification of crystalline solid products. Appropriate design and control of the crystallization …
purification of crystalline solid products. Appropriate design and control of the crystallization …
Advances and new directions in crystallization control
The academic literature on and industrial practice of control of solution crystallization
processes have seen major advances in the past 15 years that have been enabled by …
processes have seen major advances in the past 15 years that have been enabled by …
Progress and opportunities for utilizing seeding techniques in crystallization processes
Seeding is a significant but challenging task for optimizing crystallization process operation,
product quality, and process efficiency. With the development of modern crystallization …
product quality, and process efficiency. With the development of modern crystallization …
Continuous sonocrystallization of acetylsalicylic acid (ASA): Control of crystal size
RJP Eder, S Schrank, MO Besenhard… - Crystal growth & …, 2012 - ACS Publications
A continuous tubular crystallizer system with an inner diameter of 2.0 mm and an overall
length of 27 m was used to generate acetylsalicylic acid seeds in situ from ethanolic solution …
length of 27 m was used to generate acetylsalicylic acid seeds in situ from ethanolic solution …
Amorphous solid dispersions containing residual crystallinity: competition between dissolution and matrix crystallization
Crystallinity in an amorphous solid dispersion (ASD) may negatively impact dissolution
performance by causing lost solubility advantage and/or seeding crystal growth leading to …
performance by causing lost solubility advantage and/or seeding crystal growth leading to …
Comparative investigation of supersaturation and automated direct nucleation control of crystal size distributions using ATR-UV/vis spectroscopy and FBRM
The paper presents a thorough evaluation of different control strategies used in cooling
crystallization, namely, unseeded linear cooling, seeded linear cooling, supersaturation …
crystallization, namely, unseeded linear cooling, seeded linear cooling, supersaturation …
Seeding techniques and optimization of solution crystallization processes
Over the past few decades, seeding strategies for solution crystallization processes have
been developed for various applications, and significant improvements in crystal quality and …
been developed for various applications, and significant improvements in crystal quality and …
Crystal measurement technologies for crystallization processes: Advances, applications, and challenges
Crystal measurement, especially on-line measurement, in industrial crystallization is always
a challenging topic in the past years, which is crucial to precisely understand crystal …
a challenging topic in the past years, which is crucial to precisely understand crystal …
Automated continuous crystallization platform with real-time particle size analysis via laser diffraction
The fourth industrial revolution is gaining momentum in the pharmaceutical industry.
However, particulate processes and suspension handling remain big challenges for …
However, particulate processes and suspension handling remain big challenges for …
Process analytical technology-based (PAT) model simulations of a combined cooling, seeded and antisolvent crystallization of an active pharmaceutical ingredient …
Crystallization is one of the most important unit operations for production of active
pharmaceutical ingredients (API) in pharmaceutical industry. This work studied the impact of …
pharmaceutical ingredients (API) in pharmaceutical industry. This work studied the impact of …