DNA single-strand breaks (SSBs) are amongst the commonest DNA lesions arising in cells,
with many tens of thousands induced in each cell each day. SSBs arise not only from …

Cells are exposed to various endogenous and exogenous insults that induce DNA damage,
which, if unrepaired, impairs genome integrity and leads to the development of various …

Poly (ADP-ribose) is synthesized by PARP enzymes during the repair of stochastic DNA
breaks. Surprisingly, however, we show that most if not all endogenous poly (ADP-ribose) is …

CK2 (casein kinase 2) is a serine/threonine protein kinase that is ubiquitous in eukaryotic
cells and plays important roles in a variety of cellular functions, including cell growth …

Mammalian DNA base excision repair (BER) is accelerated by poly (ADP-ribose)
polymerases (PARPs) and the scaffold protein XRCC1. PARPs are sensors that detect …

Phosphoproteomics and proteomics experiments capture a global snapshot of the cellular
signaling network, but these methods do not directly measure kinase state. Kinase …

The genetic material of all organisms is susceptible to modification. In some instances, these
changes are programmed, such as the formation of DNA double strand breaks during …

Nucleosomes, the basic structural units of chromatin, hinder recruitment and activity of
various DNA repair proteins, necessitating modifications that enhance DNA accessibility …

Homeostatic mechanisms in mammals respond to hormones and nutrients to maintain blood
glucose levels within a narrow range. Caloric restriction causes many changes in glucose …

DNA double stranded breaks (DSBs) are the most cytoxic DNA lesion as the inability to
properly repair them can lead to genomic instability and tumorigenesis. The prominent DSB …