Estrogen receptors: how do they signal and what are their targets
During the past decade there has been a substantial advance in our understanding of
estrogen signaling both from a clinical as well as a preclinical perspective. Estrogen …
estrogen signaling both from a clinical as well as a preclinical perspective. Estrogen …
Computer-aided drug discovery and development (CADDD): in silico-chemico-biological approach
IM Kapetanovic - Chemico-biological interactions, 2008 - Elsevier
It is generally recognized that drug discovery and development are very time and resources
consuming processes. There is an ever growing effort to apply computational power to the …
consuming processes. There is an ever growing effort to apply computational power to the …
Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics
P Huang, V Chandra… - Annual review of …, 2010 - annualreviews.org
As ligand-regulated transcription factors, the nuclear hormone receptors are nearly ideal
drug targets, with internal pockets that bind to hydrophobic, drug-like molecules and well …
drug targets, with internal pockets that bind to hydrophobic, drug-like molecules and well …
Copper nanoparticles as inexpensive and efficient catalyst: A valuable contribution in organic synthesis
Copper nanoparticles have been explored as a new class of heterogeneous catalyst in
various chemical transformations. This review surveys the most useful organic …
various chemical transformations. This review surveys the most useful organic …
Structure–function relationship of estrogen receptor α and β: Impact on human health
17β-Estradiol (E2) controls many aspects of human physiology, including development,
reproduction and homeostasis, through regulation of the transcriptional activity of its cognate …
reproduction and homeostasis, through regulation of the transcriptional activity of its cognate …
Parallel Synthesis of a Library of Benzoxazoles and Benzothiazoles Using Ligand-Accelerated Copper-Catalyzed Cyclizations of ortho-Halobenzanilides
A general method for the formation of benzoxazoles via a copper-catalyzed cyclization of
ortho-haloanilides is reported. This approach complements the more commonly used …
ortho-haloanilides is reported. This approach complements the more commonly used …
[HTML][HTML] An ADIOL-ERβ-CtBP transrepression pathway negatively regulates microglia-mediated inflammation
Microglia and astrocytes play essential roles in the maintenance of homeostasis within the
central nervous system, but mechanisms that control the magnitude and duration of …
central nervous system, but mechanisms that control the magnitude and duration of …
COX-2-derived prostacyclin confers atheroprotection on female mice
Female gender affords relative protection from cardiovascular disease until the menopause.
We report that estrogen acts on estrogen receptor subtype alpha to up-regulate the …
We report that estrogen acts on estrogen receptor subtype alpha to up-regulate the …
Reflections on the discovery and significance of estrogen receptor β
We have known for many years that estrogen is more than the female hormone. It is
essential in the male gonads, and in both sexes, estrogen has functions in the skeleton and …
essential in the male gonads, and in both sexes, estrogen has functions in the skeleton and …
Targeting nuclear receptors in neurodegeneration and neuroinflammation
Nuclear receptors, also known as ligand-activated transcription factors, regulate gene
expression upon ligand signals and present as attractive therapeutic targets especially in …
expression upon ligand signals and present as attractive therapeutic targets especially in …