Skeletal metastases are frequent complications of many cancers, causing bone
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …

The skeleton is the most common organ to be affected by metastatic cancer and the site of
disease that produces the greatest morbidity. Skeletal morbidity includes pain that requires …

Several new systemic therapy options have become available for patients with metastatic
breast cancer, which have led to improvements in survival. In addition to patient and clinical …

Purpose This randomized study compared denosumab, a fully human monoclonal antibody
against receptor activator of nuclear factor κ B (RANK) ligand, with zoledronic acid in …

Highlights•The clinical course of advanced cancer for many patients with bone metastases
can be transformed through optimum multidisciplinary management.•Bone-targeted agents …

Purpose This study compared denosumab, a fully human monoclonal anti-receptor activator
of nuclear factor kappa-B ligand antibody, with zoledronic acid (ZA) for delaying or …

Skeletal complications caused by osteoporosis or bone metastases are associated with
considerable pain, increased mortality, and reduced quality of life. Furthermore, such events …

Bone metastasis is an incurable complication of breast cancer. In advanced stages, patients
with estrogen-positive tumors experience a significantly higher incidence of bone metastasis …

There are three distinct areas of cancer management that make bone health in cancer
patients of increasing clinical importance. First, bone metastases are common in many solid …

Background: Anaplastic thyroid cancer (ATC) is a rare but highly lethal form of thyroid
cancer. Rapid evaluation and establishment of treatment goals are imperative for optimum …