Turnitin
降AI改写
早检测系统
早降重系统
Turnitin-UK版
万方检测-期刊版
维普编辑部版
Grammarly检测
Paperpass检测
checkpass检测
PaperYY检测
A framework for establishing scientific confidence in new approach methodologies
Robust and efficient processes are needed to establish scientific confidence in new
approach methodologies (NAMs) if they are to be considered for regulatory applications …
approach methodologies (NAMs) if they are to be considered for regulatory applications …
[HTML][HTML] Application of AOPs to assist regulatory assessment of chemical risks–Case studies, needs and recommendations
While human regulatory risk assessment (RA) still largely relies on animal studies, new
approach methodologies (NAMs) based on in vitro, in silico or non-mammalian alternative …
approach methodologies (NAMs) based on in vitro, in silico or non-mammalian alternative …
Animal to human translation: a systematic sco** review of reported concordance rates
Background Drug development is currently hampered by high attrition rates; many
developed treatments fail during clinical testing. Part of the attrition may be due to low …
developed treatments fail during clinical testing. Part of the attrition may be due to low …
[HTML][HTML] An evaluation framework for new approach methodologies (NAMs) for human health safety assessment
The need to develop new tools and increase capacity to test pharmaceuticals and other
chemicals for potential adverse impacts on human health and the environment is an active …
chemicals for potential adverse impacts on human health and the environment is an active …
Probabilistic risk assessment–the keystone for the future of toxicology
Safety sciences must cope with uncertainty of models and results as well as information
gaps. Acknowledging this uncertainty necessitates embracing probabilities and accepting …
gaps. Acknowledging this uncertainty necessitates embracing probabilities and accepting …
Non-animal methods to predict skin sensitization (II): an assessment of defined approaches
Skin sensitization is a toxicity endpoint of widespread concern, for which the mechanistic
understanding and concurrent necessity for non-animal testing approaches have evolved to …
understanding and concurrent necessity for non-animal testing approaches have evolved to …
Development of a next generation risk assessment framework for the evaluation of skin sensitisation of cosmetic ingredients
N Gilmour, PS Kern, N Alépée, F Boislève… - Regulatory Toxicology …, 2020 - Elsevier
All cosmetic products placed onto the market must undergo a risk assessment for human
health to ensure they are safe for consumers, including an assessment of skin sensitisation …
health to ensure they are safe for consumers, including an assessment of skin sensitisation …
[HTML][HTML] An analysis of the limitations and uncertainties of in vivo developmental neurotoxicity testing and assessment to identify the potential for alternative …
M Paparella, SH Bennekou, A Bal-Price - Reproductive Toxicology, 2020 - Elsevier
Limitations of regulatory in vivo developmental neurotoxicity (DNT) testing and assessment
are well known, such as the 3Rs conflict, low throughput, high costs, high specific expertise …
are well known, such as the 3Rs conflict, low throughput, high costs, high specific expertise …
Use of human predictive patch test (HPPT) data for the classification of skin sensitization hazard and potency
M Herzler, J Abedini, DG Allen, D Germolec… - Archives of …, 2024 - Springer
Since the 1940s, patch tests in healthy volunteers (Human Predictive Patch Tests, HPPTs)
have been used to identify chemicals that cause skin sensitization in humans. Recently, we …
have been used to identify chemicals that cause skin sensitization in humans. Recently, we …
Pred-skin: a web portal for accurate prediction of human skin sensitizers
Safety assessment is an essential component of the regulatory acceptance of industrial
chemicals. Previously, we have developed a model to predict the skin sensitization potential …
chemicals. Previously, we have developed a model to predict the skin sensitization potential …