An unexpected role for the classical complement cascade in the elimination of central
nervous system (CNS) synapses has recently been discovered. Complement proteins are …

While Alzheimer's disease (AD) classical diagnostic criteria rely on clinical data from a
stablished symptomatic disease, newer criteria aim to identify the disease in its earlier …

Deposition of insoluble protein aggregates is a hallmark of neurodegenerative diseases.
The universal presence of β-amyloid and tau in Alzheimer's disease (AD) has facilitated …

Autosomal dominant Alzheimer's disease (ADAD) offers a unique opportunity to study
pathophysiological changes in a relatively young population with few comorbidities. A …

Metals serve important roles in the human body, including the maintenance of cell structure
and the regulation of gene expression, the antioxidant response, and neurotransmission …

Alzheimer's disease (AD) is the most common form of dementia, which is progressively
affecting elderly people. The dyshomeostasis of biometals and accumulation of toxic metals …

Biometal dyshomeostasis and toxic metal accumulation are common features in many
neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease, and …

The diagnosis of neurodegenerative disorders is often challenging due to the lack of
diagnostic tools, comorbidities and shared pathological manifestations. Synaptic dysfunction …

Most forms of Alzheimer's disease (AD) are sporadic (sAD) or inherited in a non-Mendelian
fashion, and less than 1% of cases are autosomal-dominant. Forms of sAD do not exhibit …

Immune reactions inside the central nervous system are finely regulated, thanks to the
presence of several checkpoints that have the fundamental purpose to preserve this fragile …