Handling missing data in RCTs; a review of the top medical journals
Background Missing outcome data is a threat to the validity of treatment effect estimates in
randomized controlled trials. We aimed to evaluate the extent, handling, and sensitivity …
randomized controlled trials. We aimed to evaluate the extent, handling, and sensitivity …
Missing covariate data in clinical research: when and when not to use the missing-indicator method for analysis
If missingness of a variable is related to observed characteristics but not to unobserved
characteristics, the data are (confusingly) called “missing at random.” 2, 5, 6 If data are …
characteristics, the data are (confusingly) called “missing at random.” 2, 5, 6 If data are …
Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): a randomised, double-blind, placebo-controlled, 2-year …
Background Men who are overweight or obese frequently have low serum testosterone
concentrations, which are associated with increased risk of type 2 diabetes. We aimed to …
concentrations, which are associated with increased risk of type 2 diabetes. We aimed to …
Accounting for missing data in statistical analyses: multiple imputation is not always the answer
RA Hughes, J Heron, JAC Sterne… - International journal of …, 2019 - academic.oup.com
Background Missing data are unavoidable in epidemiological research, potentially leading
to bias and loss of precision. Multiple imputation (MI) is widely advocated as an …
to bias and loss of precision. Multiple imputation (MI) is widely advocated as an …
Carvedilol reduces the risk of decompensation and mortality in patients with compensated cirrhosis in a competing-risk meta-analysis
C Villanueva, F Torres, SK Sarin, HA Shah… - Journal of …, 2022 - Elsevier
Background & Aims Whether non-selective β-blockers can prevent decompensation of
cirrhosis warrants clarification. Carvedilol might be particularly effective since its intrinsic …
cirrhosis warrants clarification. Carvedilol might be particularly effective since its intrinsic …
Effect of the serious illness care program in outpatient oncology: a cluster randomized clinical trial
R Bernacki, J Paladino, BA Neville… - JAMA internal …, 2019 - jamanetwork.com
Importance High-quality conversations between clinicians and seriously ill patients about
values and goals are associated with improved outcomes but occur infrequently. Objective …
values and goals are associated with improved outcomes but occur infrequently. Objective …
[HTML][HTML] Health care hotspotting—a randomized, controlled trial
Background There is widespread interest in programs aiming to reduce spending and
improve health care quality among “superutilizers,” patients with very high use of health care …
improve health care quality among “superutilizers,” patients with very high use of health care …
Clinical efficacy of intravitreal aflibercept versus panretinal photocoagulation for best corrected visual acuity in patients with proliferative diabetic retinopathy at 52 …
S Sivaprasad, AT Prevost, JC Vasconcelos, A Riddell… - The Lancet, 2017 - thelancet.com
Background Proliferative diabetic retinopathy is the most common cause of severe sight
impairment in people with diabetes. Proliferative diabetic retinopathy has been managed by …
impairment in people with diabetes. Proliferative diabetic retinopathy has been managed by …
[BUCH][B] Flexible imputation of missing data
S Van Buuren - 2018 - books.google.com
Missing data pose challenges to real-life data analysis. Simple ad-hoc fixes, like deletion or
mean imputation, only work under highly restrictive conditions, which are often not met in …
mean imputation, only work under highly restrictive conditions, which are often not met in …
Consumer wearable devices for evaluation of heart rate control using digoxin versus beta-blockers: the RATE-AF randomized trial
Consumer-grade wearable technology has the potential to support clinical research and
patient management. Here, we report results from the RATE-AF trial wearables study, which …
patient management. Here, we report results from the RATE-AF trial wearables study, which …