Cognitive impairment is a core feature of schizophrenia and a major contributor to poor
functional outcomes. Methods for assessment of cognitive dysfunction in schizophrenia are …

Schizophrenia is a major mental disorder that affects approximately 1% of the population
worldwide. Cognitive deficits are a key feature of the disorder and a primary cause of long …

New treatment development for psychiatric disorders depends critically upon the
development of physiological measures that can accurately translate between preclinical …

Converging evidence implicates redox dysregulation as a pathological mechanism driving
the emergence of psychosis. Increased oxidative damage and decreased capacity of …

Our brains constantly generate predictions of sensory input that are compared with actual
inputs, propagate the prediction-errors through a hierarchy of brain regions, and …

Although cortical feedback signals are essential for modulating feedforward processing, no
feedback error signal across hierarchical cortical areas has been reported. Here, we …

The neural mechanisms underlying novelty detection are not well understood, especially in
relation to behavior. Here, we present single-unit responses from the primary auditory cortex …

We developed a detailed model of macaque auditory thalamocortical circuits, including
primary auditory cortex (A1), medial geniculate body (MGB), and thalamic reticular nucleus …

Clinical outcomes vary among youths at clinical high risk for psychosis (CHR-P), with
approximately 20% progressing to full-blown psychosis over 2 to 3 years and 30% achieving …

Background Non-invasive recordings of gross neural activity in humans often show
responses to omitted stimuli in steady trains of identical stimuli. This has been taken as …