Abstract The Biomarkers of Nutrition for Development (BOND) project is designed to provide
evidence-based advice to anyone with an interest in the role of nutrition in health …

Neural tube defects (NTDs) are common complex congenital malformations resulting from
failure of the neural tube closure during embryogenesis. It is established that folic acid …

The formation of the embryonic brain and spinal cord begins as the neural plate bends to
form the neural folds, which meet and adhere to close the neural tube. The neural ectoderm …

Folate plays a key role in the interactions between nutrition, fetal programming, and
epigenomics. Maternal folate status influences DNA methylation, inheritance of the agouti …

Maternal supplementation with folic acid is known to reduce the incidence of neural tube
defects (NTDs) by as much as 70%. Despite the strong clinical link between folate and …

DNA methylation provides an attractive possible means for propagating the effects of
environmental inputs during fetal life and impacting subsequent adult mental health, which …

Neural tube defects (NTDs) are serious congenital deformities of the nervous system that
occur owing to the failure of normal neural tube closures. Genetic and non-genetic factors …

Background Neural tube defects (NTDs) are prevalent congenital defects associated with
pre-pregnancy diet with low levels of maternal folate. They are linked to severe morbidity …

Despite unequivocal evidence that folate deficiency increases risk for human pathologies,
and that folic acid intake among women of childbearing age markedly decreases risk for …

Excess vitamin intake during pregnancy leads to obesogenic phenotypes, and folic acid
accounts for many of these effects in male, but not in female, offspring. These outcomes may …