The blood–brain barrier (BBB) prevents efficient drug delivery to the central nervous system.
As a result, brain diseases remain one of the greatest unmet medical needs. Understanding …

Microfluidic technologies employ nano and microscale fabrication techniques to develop
highly controllable and reproducible fluidic microenvironments. Utilizing microfluidics, lead …

Background Alzheimer's disease (AD) is the most common neurodegenerative disorder
without effective therapy and lack diagnosis strategy for preclinical AD patients. There is an …

Glioblastoma is a most intractable and high‐mortality malignancy because of its extremely
low drug accessibility resulting from the blood–brain barrier (BBB). Here, it is reported that …

Brain cancer remains the deadliest cancer. The blood–brain barrier (BBB) is impenetrable to
most drugs and is a complex 3D network of multiple cell types including endothelial cells …

Highlights•Various approaches exist to recreate 2D and 3D structures of the
BBB.•Quantitative barrier functions in some BBB-chips are comparable to in vivo …

Gene therapy has become a promising approach for neurodegenerative disease treatment,
however there is an urgent need to develop an efficient gene carrier to transport gene …

Glioblastoma (GBM) is one of the most malignant tumors with poor prognosis and outcomes.
Although smaller particle size can lead to higher blood-brain barrier (BBB)-permeability of …

Purpose In this study, we constructed novel brain-targeting complexes (U2-AuNP) by
conjugating aptamer U2 to the gold nanoparticle (AuNPs) surface as a promising option for …

Glioblastoma (GBM) is a lethal brain cancer with a very difficult therapeutic approach and
ultimately frustrating results. Currently, therapeutic success is mainly limited by the high …