Hypoxia in solid tumors is an important predictor of poor clinical outcome to radiotherapy.
Both physicochemical and biological processes contribute to a reduced sensitivity of hypoxic …

Metastases remain the leading cause of cancer-related mortality. The oligometastasis
hypothesis postulates that a spectrum of metastatic spread exists and that some patients …

Importance The oligometastatic paradigm postulates that patients with a limited number of
metastases can be treated with ablative local therapy to each site of disease with curative …

The management of metastatic solid tumours has historically focused on systemic treatment
given with palliative intent. However, radical surgical treatment of oligometastases is now …

Background To report the primary endpoint of a randomized trial comparing pain response
following palliative stereotactic body radiation therapy (SBRT) versus conventionally …

Local treatment of metastases such as metastasectomy or radiotherapy remains
controversial in the treatment of metastatic renal cell carcinoma. To investigate the benefits …

Abstract Treatment paradigms for patients with spine metastases have evolved significantly
over the past decade. Incorporating stereotactic radiosurgery into these paradigms has been …

The oligometastatic paradigm implies that patients who develop a small number of
metastatic lesions might achieve long-term survival if all these lesions are ablated with …

Summary The SPine response assessment In Neuro-Oncology (SPINO) group is a
committee of the Response Assessment in Neuro-Oncology working group and comprises a …

We are in the midst of a technological revolution that is providing new insights into human
biology and cancer. In this era of big data, we are amassing large amounts of information …