Snakebite envenoming is a major global public health concern for which improved therapies
are urgently needed. The antigenic diversity present in snake venom toxins from various …

Cryogenic electron microscopy (cryo-EM) data represent density maps of macromolecular
systems at atomic or near-atomic resolution. However, building and refining 3D atomic …

The human cannabinoid G-protein-coupled receptors (GPCRs) CB1 and CB2 mediate the
functional responses to the endocannabinoids anandamide and 2-arachidonyl glycerol (2 …

This paper describes various components of the macromolecular crystallographic
refinement program REFMAC5, which is distributed as part of the CCP4 suite. REFMAC5 …

Pharmacological responses of G protein–coupled receptors (GPCRs) can be fine-tuned by
allosteric modulators. Structural studies of such effects have been limited due to the medium …

Muscarinic M1–M5 acetylcholine receptors are G-protein-coupled receptors that regulate
many vital functions of the central and peripheral nervous systems. In particular, the M1 and …

Here, we describe the discovery of a naturally occurring human antibody (Ab), FluA-20, that
recognizes a new site of vulnerability on the hemagglutinin (HA) head domain and reacts …

The CCP4 (Collaborative Computational Project, Number 4) software suite is a collection of
programs and associated data and software libraries which can be used for macromolecular …

The biogenic amine histamine is an important pharmacological mediator involved in
pathophysiological processes such as allergies and inflammations. Histamine H1 receptor …

For its first release in 2004, CRANK was shown to effectively detect and phase anomalous
scatterers from single-wavelength anomalous diffraction data. Since then, CRANK has been …