Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease

M Kivipelto, F Mangialasche, T Ngandu - Nature Reviews Neurology, 2018 - nature.com
Research into dementia prevention is of paramount importance if the dementia epidemic is
to be halted. Observational studies have identified several potentially modifiable risk factors …

The neurovasculome: key roles in brain health and cognitive impairment: a scientific statement from the American Heart Association/American Stroke Association

C Iadecola, EE Smith, J Anrather, C Gu, A Mishra… - Stroke, 2023 - ahajournals.org
Background: Preservation of brain health has emerged as a leading public health priority for
the aging world population. Advances in neurovascular biology have revealed an intricate …

Early-stage Alzheimer's disease prediction using machine learning models

C Kavitha, V Mani, SR Srividhya, OI Khalaf… - Frontiers in public …, 2022 - frontiersin.org
Alzheimer's disease (AD) is the leading cause of dementia in older adults. There is currently
a lot of interest in applying machine learning to find out metabolic diseases like Alzheimer's …

Risk factors for young-onset dementia in the UK Biobank

S Hendriks, JM Ranson, K Peetoom, I Lourida… - JAMA …, 2024 - jamanetwork.com
Importance There is limited information on modifiable risk factors for young-onset dementia
(YOD). Objective To examine factors that are associated with the incidence of YOD. Design …

Epilepsy in older people

A Sen, N Jette, M Husain, JW Sander - The Lancet, 2020 - thelancet.com
Globally, as populations age there will be challenges and opportunities to deliver optimal
health care to senior citizens. Epilepsy, a condition characterised by spontaneous recurrent …

TLR4 cross-talk with NLRP3 inflammasome and complement signaling pathways in Alzheimer's disease

J Yang, L Wise, K Fukuchi - Frontiers in immunology, 2020 - frontiersin.org
Amyloid plaques, mainly composed of abnormally aggregated amyloid β-protein (Aβ) in the
brain parenchyma, and neurofibrillary tangles (NFTs), consisting of hyperphosphorylated tau …

[HTML][HTML] Alzheimer's disease: treatment strategies and their limitations

E Passeri, K Elkhoury, M Morsink, K Broersen… - International journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is the most frequent case of neurodegenerative disease and is
becoming a major public health problem all over the world. Many therapeutic strategies …

Preclinical Alzheimer's disease: definition, natural history, and diagnostic criteria

B Dubois, H Hampel, HH Feldman, P Scheltens… - Alzheimer's & …, 2016 - Elsevier
During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD)
considering the disease as a continuum. Thanks to evolving biomarker research and …

Postoperative cognitive dysfunction and noncardiac surgery

LA Evered, BS Silbert - Anesthesia & Analgesia, 2018 - journals.lww.com
Postoperative cognitive dysfunction (POCD) is an objectively measured decline in cognition
postoperatively compared with preoperative function. POCD has been considered in the …

[HTML][HTML] Pathophysiologic relationship between Alzheimer's disease, cerebrovascular disease, and cardiovascular risk: a review and synthesis

CY Santos, PJ Snyder, WC Wu, M Zhang… - Alzheimer's & Dementia …, 2017 - Elsevier
As the population ages due to demographic trends and gains in life expectancy, the
incidence and prevalence of dementia increases, and the need to understand the etiology …