Advancing Synthetic Hydrogels through Nature‐Inspired Materials Chemistry

BG Soliman, AK Nguyen, JJ Gooding… - Advanced …, 2024 - Wiley Online Library
Synthetic extracellular matrix (ECM) mimics that can recapitulate the complex biochemical
and mechanical nature of native tissues are needed for advanced models of development …

Engineered protein hydrogels as biomimetic cellular scaffolds

Y Liu, AE Gilchrist, SC Heilshorn - Advanced materials, 2024 - Wiley Online Library
The biochemical and biophysical properties of the extracellular matrix (ECM) play a pivotal
role in regulating cellular behaviors such as proliferation, migration, and differentiation …

Novel natural polymer‐based hydrogel patches with Janus asymmetric‐adhesion for emergency hemostasis and wound healing

L Sun, J Zhou, J Lai, X Zheng, H Wang… - Advanced Functional …, 2024 - Wiley Online Library
An asymmetrical wound dressing functions akin to human skin by serving as a protective
barrier between a wound and its immediate environment. However, significant challenges …

Harnessing mechanical stress with viscoelastic biomaterials for periodontal ligament regeneration

JJ Zhang, X Li, Y Tian, JK Zou, D Gan… - Advanced …, 2024 - Wiley Online Library
The viscoelasticity of mechanically sensitive tissues such as periodontal ligaments (PDLs) is
key in maintaining mechanical homeostasis. Unfortunately, PDLs easily lose viscoelasticity …

[HTML][HTML] Schiff base crosslinked hyaluronic acid hydrogels with tunable and cell instructive time-dependent mechanical properties

TB Kohlan, Y Wen, C Mini, A Finne-Wistrand - Carbohydrate Polymers, 2024 - Elsevier
The dynamic interplay between cells and their native extracellular matrix (ECM) influences
cellular behavior, imposing a challenge in biomaterial design. Dynamic covalent hydrogels …

Substrate stress relaxation regulates neural stem cell fate commitment

E Qiao, CA Fulmore, DV Schaffer, S Kumar - Proceedings of the National …, 2024 - pnas.org
Adult neural stem cells (NSCs) reside in the dentate gyrus of the hippocampus, and their
capacity to generate neurons and glia plays a role in learning and memory. In addition …

Viscoelastic cues to induce stem cell migration and neuronal differentiation in cell-free hydrogel-assisted TBI recovery

X Liu, C Wu, Y Zhang, G Li, S Chen, Z Chen… - Chemical Engineering …, 2024 - Elsevier
The concept of tissue-inducing biomaterials, such as osteoinductive biomaterials, has
inspired the design of regenerative material with biomimetic cues to manipulate cell/tissue …

Multi‐Functional Gelatin‐Dithiolane Hydrogels for Tissue Engineering

S Asim, C Tuftee, AT Qureshi… - Advanced Functional …, 2025 - Wiley Online Library
Biomaterials that integrate multiple functionalities, mimic the extracellular matrix (ECM)
microenvironment to support cellular growth, and adhere robustly to damaged tissues are …

Complex in vitro models positioned for impact to drug testing in pharma: a review

S Kang, EC Chen, H Cifuentes, G Cole, J Graham… - …, 2024 - iopscience.iop.org
Recent years have seen the creation and popularization of various complex in vitro models
(CIVMs), such as organoids and organs-on-chip, as a technology with the potential to …

[HTML][HTML] Emerging hydrogel therapies for translating brain disease: Materials, mechanisms, and recent research

X Lu, Y Luo, X Hu, J Chu, S Li, M Hao, J Zhuang… - Materials Today …, 2024 - Elsevier
Brain diseases, encompassing neurodegenerative disorders, strokes, and brain tumors,
represent significant medical conditions with profound implications for human health. The …