Advancing Synthetic Hydrogels through Nature‐Inspired Materials Chemistry
Synthetic extracellular matrix (ECM) mimics that can recapitulate the complex biochemical
and mechanical nature of native tissues are needed for advanced models of development …
and mechanical nature of native tissues are needed for advanced models of development …
Engineered protein hydrogels as biomimetic cellular scaffolds
The biochemical and biophysical properties of the extracellular matrix (ECM) play a pivotal
role in regulating cellular behaviors such as proliferation, migration, and differentiation …
role in regulating cellular behaviors such as proliferation, migration, and differentiation …
Complex in vitro models positioned for impact to drug testing in pharma: a review
S Kang, EC Chen, H Cifuentes, G Cole, J Graham… - …, 2024 - iopscience.iop.org
Recent years have seen the creation and popularization of various complex in vitro models
(CIVMs), such as organoids and organs-on-chip, as a technology with the potential to …
(CIVMs), such as organoids and organs-on-chip, as a technology with the potential to …
Hydrogels mimicking the viscoelasticity of extracellular matrix for regenerative medicine: Design, application, and molecular mechanism
L Li, S Wang, Y Chen, S Dong, C Zhang, L Liao… - Chemical Engineering …, 2024 - Elsevier
The extracellular matrix (ECM) provides a dynamic microenvironment for cells, which has
time-responsive mechanical properties such as hysteresis, relaxation, and creep …
time-responsive mechanical properties such as hysteresis, relaxation, and creep …
Sensorable zwitterionic antibacterial hydrogel for wound electrostimulation therapy
J Li, M Chen, S Cheng, S Gao, J Zhai, D Yu, J Wang… - Biomaterials, 2025 - Elsevier
Wound healing process has always been a focal point of concern, with a plethora of
hydrogel dressings available; however, their therapeutic efficacy remains a hindrance to …
hydrogel dressings available; however, their therapeutic efficacy remains a hindrance to …
A Library of Elastin-like Proteins with Tunable Matrix Ligands for In Vitro 3D Neural Cell Culture
Hydrogels with encapsulated cells have widespread biomedical applications, both as tissue-
mimetic 3D cultures in vitro and as tissue-engineered therapies in vivo. Within these …
mimetic 3D cultures in vitro and as tissue-engineered therapies in vivo. Within these …
Multi‐Functional Gelatin‐Dithiolane Hydrogels for Tissue Engineering
Biomaterials that integrate multiple functionalities, mimic the extracellular matrix (ECM)
microenvironment to support cellular growth, and adhere robustly to damaged tissues are …
microenvironment to support cellular growth, and adhere robustly to damaged tissues are …
Actuating Extracellular Matrices Decouple the Mechanical and Biochemical Effects of Muscle Contraction on Motor Neurons
Emerging in vivo evidence suggests that repeated muscle contraction, or exercise, impacts
peripheral nerves. However, the difficulty of isolating the muscle‐specific impact on motor …
peripheral nerves. However, the difficulty of isolating the muscle‐specific impact on motor …
Viscoelasticity of Hyaluronic Acid Hydrogels Regulates Human Pluripotent Stem Cell‐derived Spinal Cord Organoid Patterning and Vascularization
Recently, it has been recognized that natural extracellular matrix (ECM) and tissues are
viscoelastic, while only elastic properties have been investigated in the past. How the …
viscoelastic, while only elastic properties have been investigated in the past. How the …
[HTML][HTML] 3D bioprinted dynamic bioactive living construct enhances mechanotransduction-assisted rapid neural network self-organization for spinal cord injury repair
Biomimetic neural substitutes, constructed through the bottom-up assembly of cell-matrix
modulus via 3D bioprinting, hold great promise for neural regeneration. However, achieving …
modulus via 3D bioprinting, hold great promise for neural regeneration. However, achieving …