Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a
transmembrane protein, amyloid precursor protein (APP), by β-and γ-secretases. Aβ …

Slowly but surely, Alzheimer's disease (AD) patients lose their memory and their cognitive
abilities, and even their personalities may change dramatically. These changes are due to …

A central unresolved problem in research on Alzheimer disease is the nature of the
molecular entity causing dementia. Here we provide the first direct experimental evidence …

▪ Abstract Many neurodegenerative diseases, including Alzheimer's and Parkinson's and the
transmissible spongiform encephalopathies (prion diseases), are characterized at autopsy …

Protein conformational diseases, including Alzheimer's, Huntington's, and Parkinson's
diseases, result from protein misfolding, giving a distinct fibrillar feature termed amyloid …

Autophagy is the sole pathway for organelle turnover in cells and is a vital pathway for
degrading normal and aggregated proteins, particularly under stress or injury conditions …

Alzheimer's disease (AD) is the most common neurodegenerative disorder and the most
prevalent cause of dementia with ageing. Pharmacological treatment of AD is based on the …

The cause of Alzheimer's disease (AD) is unknown. This gap in knowledge has created a
stumbling block in the search for a genuinely effective treatment or cure for this dementia …

A wide variety of neurodegenerative diseases are characterized by the accumulation of
intracellular or extracellular protein aggregates. More recently, the genetic identification of …

The accumulation of amyloid β‐protein (Aβ) in brain regions serving memory and cognition
is a central pathogenic feature of Alzheimer's disease (AD). We have shown that small …