Redox signaling by reactive electrophiles and oxidants
The concept of cell signaling in the context of nonenzyme-assisted protein modifications by
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …
The 4-hydroxynonenal–protein adducts and their biological relevance: are some proteins preferred targets?
It is well known that oxidative stress and lipid peroxidation (LPO) play a role in physiology
and pathology. The most studied LPO product with pleiotropic capabilities is 4 …
and pathology. The most studied LPO product with pleiotropic capabilities is 4 …
Click-ExM enables expansion microscopy for all biomolecules
Expansion microscopy (ExM) allows super-resolution imaging on conventional fluorescence
microscopes, but has been limited to proteins and nucleic acids. Here we develop click-ExM …
microscopes, but has been limited to proteins and nucleic acids. Here we develop click-ExM …
Quantitative profiling of protein carbonylations in ferroptosis by an aniline-derived probe
Ferroptosis is a regulated form of necrotic cell death implicated in carcinogenesis and
neurodegeneration that is driven by phospholipid peroxidation. Lipid-derived electrophiles …
neurodegeneration that is driven by phospholipid peroxidation. Lipid-derived electrophiles …
Recent progress of oxidative stress associated biomarker detection
J Li, L Pan, W Pan, N Li, B Tang - Chemical Communications, 2023 - pubs.rsc.org
Oxidative stress denotes the imbalance between the generation of reactive oxygen species
(ROS) and antioxidant defenses in living organisms, participating in various …
(ROS) and antioxidant defenses in living organisms, participating in various …
Reactive-cysteine profiling for drug discovery
AJ Maurais, E Weerapana - Current Opinion in Chemical Biology, 2019 - Elsevier
The recognition that only a small percentage of known human gene products are druggable
using traditional modes of non-covalent ligand design, has led to a resurgence in targeted …
using traditional modes of non-covalent ligand design, has led to a resurgence in targeted …
Unexpected complexity in the products arising from NaOH-, heat-, amine-, and glycosylase-induced strand cleavage at an abasic site in DNA
Hydrolytic loss of nucleobases from the deoxyribose backbone of DNA is one of the most
common unavoidable types of damage in synthetic and cellular DNA. The reaction …
common unavoidable types of damage in synthetic and cellular DNA. The reaction …
Biochemical genesis of enzymatic and non-enzymatic post-translational modifications
Post-translational modifications (PTMs) alter protein structure, function, and localization and
play a pivotal role in physiological and pathophysiological conditions. Many PTMs arise from …
play a pivotal role in physiological and pathophysiological conditions. Many PTMs arise from …
Protein lipoxidation: basic concepts and emerging roles
Á Viedma-Poyatos, P González-Jiménez, O Langlois… - Antioxidants, 2021 - mdpi.com
Protein lipoxidation is a non-enzymatic post-translational modification that consists of the
covalent addition of reactive lipid species to proteins. This occurs under basal conditions but …
covalent addition of reactive lipid species to proteins. This occurs under basal conditions but …
A dimethyl-labeling-based strategy for site-specifically quantitative chemical proteomics
Activity-based protein profiling (ABPP) has emerged as a powerful functional
chemoproteomic strategy which enables global profiling of proteome reactivity toward …
chemoproteomic strategy which enables global profiling of proteome reactivity toward …