Depression is a common, devastating illness. Current pharmacotherapies help many
patients, but high rates of a partial response or no response, and the delayed onset of the …

As humans, we perceive feelings from our bodies that relate our state of well-being, our
energy and stress levels, our mood and disposition. How do we have these feelings? What …

How the Body Shapes the Mind is an interdisciplinary work that addresses philosophical
questions by appealing to evidence found in experimental psychology, neuroscience …

Researchers have wondered how the brain creates emotions since the early days of
psychological science. With a surge of studies in affective neuroscience in recent decades …

Historically, the locus coeruleus-norepinephrine (LC-NE) system has been implicated in
arousal, but recent findings suggest that this system plays a more complex and specific role …

Medial prefrontal cortex (MPFC) is among those brain regions having the highest baseline
metabolic activity at rest and one that exhibits decreases from this baseline across a wide …

This paper reviews architectonic subdivisions and connections of the orbital and medial
prefrontal cortex (OMPFC) in rats, monkeys and humans. Cortico-cortical connections …

Why does performing certain tasks cause the aversive experience of mental effort and
concomitant deterioration in task performance? One explanation posits a physical resource …

The orbitofrontal cortex in primates including humans is the key brain area in emotion, and
in the representation of reward value and in non-reward, that is not obtaining an expected …

Hedonic experience is arguably at the heart of what makes us human. In recent
neuroimaging studies of the cortical networks that mediate hedonic experience in the human …