Interpreting protein chemical shift data
DS Wishart - Progress in nuclear magnetic resonance spectroscopy, 2011 - Elsevier
Chemical shifts are the mileposts of NMR. For more than 60 years [1, 2], they have been
used by chemists as highly reproducible, easily measured parameters to map out the …
used by chemists as highly reproducible, easily measured parameters to map out the …
Functional aspects of protein flexibility
Proteins are dynamic entities, and they possess an inherent flexibility that allows them to
function through molecular interactions within the cell, among cells and even between …
function through molecular interactions within the cell, among cells and even between …
Combined automated NOE assignment and structure calculation with CYANA
P Güntert, L Buchner - Journal of biomolecular NMR, 2015 - Springer
The automated assignment of NOESY cross peaks has become a fundamental technique for
NMR protein structure analysis. A widely used algorithm for this purpose is implemented in …
NMR protein structure analysis. A widely used algorithm for this purpose is implemented in …
Reciprocal antagonism of PIN1-APC/CCDH1 governs mitotic protein stability and cell cycle entry
Induced oncoproteins degradation provides an attractive anti-cancer modality. Activation of
anaphase-promoting complex (APC/CCDH1) prevents cell-cycle entry by targeting crucial …
anaphase-promoting complex (APC/CCDH1) prevents cell-cycle entry by targeting crucial …
The ambivalent role of proline residues in an intrinsically disordered protein: from disorder promoters to compaction facilitators
Intrinsically disordered proteins (IDPs) carry out many biological functions. They lack a
stable three-dimensional structure, but rather adopt many different conformations in dynamic …
stable three-dimensional structure, but rather adopt many different conformations in dynamic …
The TDP‐43 N‐terminal domain structure at high resolution
Transactive response DNA‐binding protein 43 kDa (TDP‐43) is an RNA transporting and
processing protein whose aberrant aggregates are implicated in neurodegenerative …
processing protein whose aberrant aggregates are implicated in neurodegenerative …
O-GlcNAc modification of tau directly inhibits its aggregation without perturbing the conformational properties of tau monomers
SA Yuzwa, AH Cheung, M Okon, LP McIntosh… - Journal of molecular …, 2014 - Elsevier
The aggregation of the microtubule-associated protein tau into paired helical filaments to
form neurofibrillary tangles constitutes one of the pathological hallmarks of Alzheimer's …
form neurofibrillary tangles constitutes one of the pathological hallmarks of Alzheimer's …
Prediction of Xaa-Pro peptide bond conformation from sequence and chemical shifts
We present a program, named Promega, to predict the Xaa-Pro peptide bond conformation
on the basis of backbone chemical shifts and the amino acid sequence. Using a chemical …
on the basis of backbone chemical shifts and the amino acid sequence. Using a chemical …
Proline cis-trans isomerization controls autoinhibition of a signaling protein
P Sarkar, C Reichman, T Saleh, RB Birge… - Molecular cell, 2007 - cell.com
Autoinhibition is being widely used in nature to repress otherwise constitutive protein
activities and is typically regulated by extrinsic factors. Here we show that autoinhibition can …
activities and is typically regulated by extrinsic factors. Here we show that autoinhibition can …
PREDITOR: a web server for predicting protein torsion angle restraints
Every year between 500 and 1000 peptide and protein structures are determined by NMR
and deposited into the Protein Data Bank. However, the process of NMR structure …
and deposited into the Protein Data Bank. However, the process of NMR structure …