Cell type-specific gene expression relies on transcription factors (TFs) binding DNA
sequence motifs embedded in chromatin. Understanding how motifs are accessed in …

Nucleosome positioning is critical for gene expression and most DNA-related processes.
Here we review the dominant patterns of nucleosome positioning that have been observed …

Plants are highly sensitive to temperature and can perceive a difference of as little as 1° C.
How temperature is sensed and integrated in development is unknown. In a forward genetic …

Ever since the beginning of biochemical analysis, yeast has been a pioneering model for
studying the regulation of eukaryotic metabolism. During the last three decades, the …

Morphogens are long-range signaling molecules that pattern develo** tissues in a
concentration-dependent manner. The graded activity of morphogens within tissues …

Despite extensive research, our understanding of the rules according to which cis-regulatory
sequences are converted into gene expression is limited. We devised a method for …

In the eukaryotic genome, the thousands of genes that encode messenger RNA are
transcribed by a molecular machine called RNA polymerase II. Analysing the distribution …

In eukaryotes, all DNA-templated reactions occur in the context of chromatin. Nucleosome
packaging inherently restricts DNA accessibility for regulatory proteins but also provides an …

The chromatin environment is essential for the correct specification and preservation of cell
identity through modulation and maintenance of transcription patterns. Many chromatin …

The regulation of gene transcription involves a dynamic balance between packaging
regulatory sequences into chromatin and allowing transcriptional regulators access to these …