Recovery from disorders of consciousness: mechanisms, prognosis and emerging therapies

BL Edlow, J Claassen, ND Schiff… - Nature Reviews Neurology, 2021 - nature.com
Substantial progress has been made over the past two decades in detecting, predicting and
promoting recovery of consciousness in patients with disorders of consciousness (DoC) …

[HTML][HTML] Conscious processing and the global neuronal workspace hypothesis

GA Mashour, P Roelfsema, JP Changeux, S Dehaene - Neuron, 2020 - cell.com
We review the central tenets and neuroanatomical basis of the global neuronal workspace
(GNW) hypothesis, which attempts to account for the main scientific observations regarding …

European Academy of Neurology guideline on the diagnosis of coma and other disorders of consciousness

D Kondziella, A Bender, K Diserens… - European journal of …, 2020 - Wiley Online Library
Background and purpose Patients with acquired brain injury and acute or prolonged
disorders of consciousness (DoC) are challenging. Evidence to support diagnostic decisions …

Quantifying arousal and awareness in altered states of consciousness using interpretable deep learning

M Lee, LRD Sanz, A Barra, A Wolff… - Nature …, 2022 - nature.com
Consciousness can be defined by two components: arousal (wakefulness) and awareness
(subjective experience). However, neurophysiological consciousness metrics able to …

Robust EEG-based cross-site and cross-protocol classification of states of consciousness

DA Engemann, F Raimondo, JR King, B Rohaut… - Brain, 2018 - academic.oup.com
Determining the state of consciousness in patients with disorders of consciousness is a
challenging practical and theoretical problem. Recent findings suggest that multiple markers …

Clinical and advanced neurophysiology in the prognostic and diagnostic evaluation of disorders of consciousness: review of an IFCN-endorsed expert group

A Comanducci, M Boly, J Claassen, M De Lucia… - Clinical …, 2020 - Elsevier
The analysis of spontaneous EEG activity and evoked potentials is a cornerstone of the
instrumental evaluation of patients with disorders of consciousness (DoC). The past few …

Preservation of brain activity in unresponsive patients identifies MCS star

A Thibaut, R Panda, J Annen, LRD Sanz… - Annals of …, 2021 - Wiley Online Library
Objective Brain‐injured patients who are unresponsive at the bedside (ie, vegetative
state/unresponsive wakefulness syndrome–VS/UWS) may present brain activity similar to …

Accuracy of EEG biomarkers in the detection of clinical outcome in disorders of consciousness after severe acquired brain injury: preliminary results of a pilot study …

F Di Gregorio, F La Porta, V Petrone, S Battaglia… - Biomedicines, 2022 - mdpi.com
Accurate outcome detection in neuro-rehabilitative settings is crucial for appropriate long-
term rehabilitative decisions in patients with disorders of consciousness (DoC). EEG …

Consciousness and complexity: a consilience of evidence

S Sarasso, AG Casali, S Casarotto… - Neuroscience of …, 2021 - academic.oup.com
Over the last years, a surge of empirical studies converged on complexity-related measures
as reliable markers of consciousness across many different conditions, such as sleep …

Tau burden and the functional connectome in Alzheimer's disease and progressive supranuclear palsy

TE Cope, T Rittman, RJ Borchert, PS Jones… - Brain, 2018 - academic.oup.com
Alzheimer's disease and progressive supranuclear palsy (PSP) represent
neurodegenerative tauopathies with predominantly cortical versus subcortical disease …