NMR spectroscopy is a powerful tool for biologists interested in the structure, dynamics, and
interactions of biological macromolecules. This review aims at presenting in an accessible …

The objective of this review is to enable researchers to use the software package Rosetta for
biochemical and biomedicinal studies. We provide a brief review of the six most frequent …

The AlphaFold Protein Structure Database contains predicted structures for millions of
proteins. For the majority of human proteins that contain intrinsically disordered regions …

Abstract A new program, TALOS-N, is introduced for predicting protein backbone torsion
angles from NMR chemical shifts. The program relies far more extensively on the use of …

Abstract α-synuclein aggregation is implicated in a variety of diseases including Parkinson's
disease, dementia with Lewy bodies, pure autonomic failure and multiple system atrophy …

Expression of the INK4b/ARF/INK4a tumor suppressor locus in normal and cancerous cell
growth is controlled by methylation of histone H3 at lysine 27 (H3K27me) as directed by the …

NMR chemical shifts in proteins depend strongly on local structure. The program TALOS
establishes an empirical relation between 13 C, 15 N and 1 H chemical shifts and backbone …

The Rosetta molecular modeling software package provides experimentally tested and
rapidly evolving tools for the 3D structure prediction and high-resolution design of proteins …

Amyloid fibrils commonly exhibit multiple distinct morphologies in electron microscope and
atomic force microscope images, often within a single image field. By using electron …

CXCR1 is one of two high-affinity receptors for the CXC chemokine interleukin-8 (IL-8), a
major mediator of immune and inflammatory responses implicated in many disorders …