Exosomes are nanoparticles secreted by all cell types and are a large component of the
broader class of nanoparticles termed extracellular vesicles (EVs). Once secreted …

Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

miRNAs can be found in serum and other body fluids and serve as biomarkers for disease.
More importantly, secreted miRNAs, especially those in extracellular vesicles (EVs) such as …

Over the past decade, great progress has been made in understanding the complexity of
adipose tissue biology and its role in metabolism. This includes new insights into the …

Oxidative stress and inflammation interact in the development of diabetic atherosclerosis.
Intracellular hyperglycemia promotes production of mitochondrial reactive oxygen species …

Obesity is a complex condition that is characterized by excessive fat accumulation, which
can lead to the development of metabolic disorders, such as type 2 diabetes mellitus …

During the last decade, there has been great interest in elucidating the biological role of
extracellular vesicles (EVs), particularly, their hormone-like role in cell-to-cell …

Epidemiological studies demonstrate an association between breast cancer (BC) and
systemic dysregulation of glucose metabolism. However, how BC influences glucose …

RNA interference (RNAi) is considered a highly specific approach for gene silencing and
holds tremendous potential for treatment of various pathologic conditions such as …

Background The prevalence and incidence of type 2 diabetes (T2D), representing> 90% of
all cases of diabetes, are increasing rapidly worldwide. Identification of individuals at high …