Artemisinin contains an endoperoxide moiety that can react with iron to form cytotoxic free
radicals. Cancer cells contain significantly more intracellular free iron than normal cells and …

Although cytosolic glutathione S-transferase (GST) enzymes occupy a key position in
biological detoxification processes, two of the most relevant human isoenzymes, GSTT1-1 …

Secondary metabolites from plants can serve as defense against herbivores, microbes,
viruses or competing plants. Many compounds from medicinal plants have pharmacological …

Drug resistance of tumor cells is recognized as the primary cause of failure of
chemotherapeutic treatment of most human tumors. Although pharmacological factors …

Artemisinin, a sesquiterpene lactone derived from the sweet wormwood plant Artemisia
annua, and its bioactive derivatives exhibit potent anticancer effects in a variety of human …

Abstract Purpose Glutathione S-transferases (GSTs) family of enzymes is best known for
their cytoprotective role and their involvement in the development of anticancer drug …

Abstract Glutathione S‐transferases (EC 2.5. 1.18, GSTs), consisting of at least seven
subfamilies, such as alpha, kappa, mu, pi, theta, zeta, and omega, are the family of cytosolic …

In addition to their well-known anti-malarial activity, artemisinin and its derivatives (1, 2, 4-
trioxanes) possess potent activity against tumor cells in the nano-to micromolar range …

Dihydroartemisinin (DHA), the main active metabolite of artemisinin derivatives, is one of the
most effective anti-malarial analogs of artemisinin. In the current study, we found that DHA …

Glutathione S-transferases (GSTs) are multifunctional detoxification proteins that protect the
cell from electrophilic compounds. Overexpression of GSTs in cancer results in resistance to …