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From a binding module to essential catalytic activity: how nature stumbled on a good thing
Enzymes are complex macromolecules capable of catalyzing a wide variety of chemical
reactions with high efficiency. Nonetheless, biological catalysis can be rudimentary. Here …
reactions with high efficiency. Nonetheless, biological catalysis can be rudimentary. Here …
Crystal structure of the plasmid-encoded R67 dihydrofolate reductase complexed with Congo red an amyloid binding dye
AN Narendra, EE Howell, N Narayana - Scientific Reports, 2025 - nature.com
Plasmid-encoded bacterial R67 dihydrofolate reductase (DHFR) catalyzes the same
reaction as the chromosomal counterpart but is highly resistant to the widely used antibiotic …
reaction as the chromosomal counterpart but is highly resistant to the widely used antibiotic …
Discovery of highly trimethoprim-resistant DfrB dihydrofolate reductases in diverse environmental settings suggests an evolutionary advantage unrelated to antibiotic …
S Cellier-Goetghebeur, K Lafontaine… - Antibiotics, 2022 - mdpi.com
Type B dihydrofolate reductases (DfrB) are intrinsically highly resistant to the widely used
antibiotic trimethoprim, posing a threat to global public health. The ten known DfrB family …
antibiotic trimethoprim, posing a threat to global public health. The ten known DfrB family …
[HTML][HTML] Photoaffinity probe-enabled discovery of sennoside A reductase in Bifidobacterium pseudocatenulatum
Y Xu, S Lv, X Li, C Zhai, Y Shi, X Li, Z Feng… - Journal of …, 2025 - Elsevier
Sennoside A (SA), a typical prodrug, exerts its laxative effect only after its transformation into
rheinanthrone catalyzed by gut microbial hydrolases and reductases. Hydrolases have been …
rheinanthrone catalyzed by gut microbial hydrolases and reductases. Hydrolases have been …
Bacteria of the order Burkholderiales are original environmental hosts of type II trimethoprim resistance genes (dfrB)
D Kneis, F Tskhay, M de la Cruz Barron… - The ISME …, 2024 - academic.oup.com
It is consensus that clinically relevant antibiotic resistance genes have their origin in
environmental bacteria, including the large pool of primarily benign species. Yet, for the vast …
environmental bacteria, including the large pool of primarily benign species. Yet, for the vast …
Trimethoprim resistance in surface and wastewater is mediated by contrasting variants of the dfrB gene
Trimethoprim (TMP) is a low-cost, widely prescribed antibiotic. Its effectiveness is
increasingly challenged by the spread of genes coding for TMP-resistant dihydrofolate …
increasingly challenged by the spread of genes coding for TMP-resistant dihydrofolate …
Reactivity and mechanism in chemical and synthetic biology
NGJ Richards, SL Bearne, Y Goto… - … Transactions of the …, 2023 - royalsocietypublishing.org
Physical organic chemistry and mechanistic thinking provide a strong intellectual framework
for understanding the chemical logic of evolvable informational macromolecules and …
for understanding the chemical logic of evolvable informational macromolecules and …