Spinal cord injury: molecular mechanisms and therapeutic interventions

X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - Signal transduction and …, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

Electrical stimulation affects neural stem cell fate and function in vitro

R Zhu, Z Sun, C Li, S Ramakrishna, K Chiu, L He - Experimental neurology, 2019 - Elsevier
Electrical stimulation (ES) has been applied in cell culture system to enhance neural stem
cell (NSC) proliferation, neuronal differentiation, migration, and integration. According to the …

Grooved fibers: Preparation principles through electrospinning and potential applications

L Zhan, J Deng, Q Ke, X Li, Y Ouyang, C Huang… - Advanced Fiber …, 2022 - Springer
The surface morphology of micro-and nano-scale fiber determines its application to a great
extent. At present, a variety of secondary morphology of microfibers and nanofibers, such as …

[HTML][HTML] Engineered M13 phage as a novel therapeutic bionanomaterial for clinical applications: From tissue regeneration to cancer therapy

C Chang, W Guo, X Yu, C Guo, N Zhou, X Guo… - Materials Today Bio, 2023 - Elsevier
Bacteriophages (phages) are nanostructured viruses with highly selective antibacterial
properties that have gained attention beyond eliminating bacteria. Specifically, M13 phages …

Electrical stimulation promotes stem cell neural differentiation in tissue engineering

H Cheng, Y Huang, H Yue, Y Fan - Stem cells international, 2021 - Wiley Online Library
Nerve injuries and neurodegenerative disorders remain serious challenges, owing to the
poor treatment outcomes of in situ neural stem cell regeneration. The most promising …

Antioxidative and conductive nanoparticles-embedded cell niche for neural differentiation and spinal cord injury repair

C Wu, S Chen, T Zhou, K Wu, Z Qiao… - … applied materials & …, 2021 - ACS Publications
Following spinal cord injury (SCI), the transmission of electrical signals is interrupted, and an
oxidative microenvironment is generated, hindering nerve regeneration and functional …

A therapeutic convection–enhanced macroencapsulation device for enhancing β cell viability and insulin secretion

K Yang, ED O'Cearbhaill, SS Liu… - Proceedings of the …, 2021 - National Acad Sciences
Islet transplantation for type 1 diabetes treatment has been limited by the need for lifelong
immunosuppression regimens. This challenge has prompted the development of …

Delivering mechanical stimulation to cells: state of the art in materials and devices design

Y Zhang, P Habibovic - Advanced Materials, 2022 - Wiley Online Library
Biochemical signals, such as growth factors, cytokines, and transcription factors are known
to play a crucial role in regulating a variety of cellular activities as well as maintaining the …

Piezoelectric nanotopography induced neuron‐like differentiation of stem cells

X Zhang, X Cui, D Wang, S Wang, Z Liu… - Advanced Functional …, 2019 - Wiley Online Library
The biophysical characteristics of the extracellular matrix, such as nanotopography and
bioelectricity, have a profound influence on cell proliferation, adhesion, differentiation, etc …

Coordinated Biophysical Stimulation of MSCs via Electromagnetized Au‐Nanofiber Matrix Regulates Cytoskeletal‐to‐Nuclear Mechanoresponses and Lineage …

RK Singh, AG Kurian, V Sagar, I Park… - Advanced Functional …, 2023 - Wiley Online Library
Biophysical stimulation regulates stem cell functions, including proliferation and
differentiation. Matrix nanotopography and external forces, such as electromagnetic fields …