Phase Separation–Mediated Compartmentalization Underlies Synapse Formation and Plasticity

X Wu, Z Shen, M Zhang - Annual Review of Neuroscience, 2025 - annualreviews.org
The synapse is polarized and highly compartmentalized on both its pre-and postsynaptic
sides. The compartmentalization of synaptic vesicles, as well as vesicle releasing and …

Phase separation in the multi-compartment organization of synapses

S Zhu, Z Shen, X Wu, M Zhang - Current Opinion in Neurobiology, 2025 - Elsevier
A neuronal synapse is formed by juxtaposition of a transmitter releasing presynaptic bouton
of one neuron with a transmitter receiving postsynaptic compartment such as a spine …

The TrkC-PTPσ complex governs synapse maturation and anxiogenic avoidance via synaptic protein phosphorylation

H Khaled, Z Ghasemi, M Inagaki, K Patel… - The EMBO …, 2024 - embopress.org
The precise organization of pre-and postsynaptic terminals is crucial for normal synaptic
function in the brain. In addition to its canonical role as a neurotrophin-3 receptor tyrosine …

[HTML][HTML] Characterization of Dynamin-related proteins (DRP) in bread wheat: TaDRP1D-B as regulator of biotic and abiotic stresses

Z Wang, A Shafique, B Yu, B Alharthi, N Ali… - Plant Stress, 2024 - Elsevier
Bread wheat (Triticum aestivum) is a vital global staple food, providing 30% of the world's
caloric intake and nutritional needs. It was domesticated over 10,000 years ago and adapted …

Handshaking for ultrafast endocytosis: Dynamin1xA and Endophilin A1 sealed the deal

S López-Begines, R Fernández-Chacón - The EMBO Journal, 2024 - embopress.org
Brain function relies on quick inter-neuron communication at specialized points of contact
termed synapses. In the latest issue of The EMBO Journal, Imoto, Xue, et al (2024) report the …

Ultrastructural membrane dynamics of mouse and human cortical synapses

CR Eddings, M Fan, Y Imoto, K Itoh, X McDonald… - bioRxiv, 2024 - biorxiv.org
Live human brain tissues provide unique opportunities for understanding the physiology and
pathophysiology of synaptic transmission. Investigations have been limited to anatomy …