Calcium ions are the major signaling ions in the cells. They regulate muscle contraction,
neurotransmitter secretion, cell growth and migration, and the activity of several proteins …

Neuromuscular diseases (NMDs) are characterized by progressive loss of muscle mass and
strength that leads to impaired body movement. It not only severely diminishes the quality of …

Transient receptor potential melastatin 4 (TRPM4) is a unique member of the TRPM protein
family and, similarly to TRPM5, is Ca2+ sensitive and permeable for monovalent but not …

Alternative RNA splicing, a ubiquitous mechanism of gene regulation in eukaryotes,
expands genome coding capacity and proteomic diversity. It has essential roles in all …

Protein arginine methyltransferases (PRMTs) modify diverse protein targets and regulate
numerous cellular processes; yet, their contributions to individual effector T cell responses …

Retinoic acid receptor–related orphan receptor α (RORα) is a transcription factor involved in
nuclear gene expression and a known tumor suppressor. RORα was the first identified …

PRMT5 is a widely expressed arginine methyltransferase that regulates processes involved
in tumor cell proliferation and survival. In the study described here, we investigated whether …

Protein arginine methyltransferase (PRMT) 5 is an essential arginine methyltransferase
responsible for the majority of cellular symmetric dimethyl-arginine marks. PRMT5 uses …

The increasing incidence and mortality associated with lung cancer (LC) is a significant
global health challenge. The underlying mechanisms contributing to LC remain …

Tumor hypoxia induced alterations in the epigenetic landscape and alternative splicing
influence cellular adaptations. PRMT5 is a type II protein arginine methyltransferase that …