Circulating tumor cells (CTCs) are the seeds of distant metastasis, and the number of CTCs
detected in the blood of cancer patients is associated with a worse prognosis. CTCs face …

Definitive haematopoiesis is the process by which haematopoietic stem cells, located in the
bone marrow, generate all haematopoietic cell lineages in healthy adults. Although highly …

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly
across the USA, causing extensive morbidity and mortality, particularly in the African …

Classically, platelets have been described as the cellular blood component that mediates
hemostasis and thrombosis. This important platelet function has received significant …

Platelet dysregulation is drastically increased with advanced age and contributes to making
cardiovascular disorders the leading cause of death of elderly humans. Here, we reveal a …

A lack of models that recapitulate the complexity of human bone marrow has hampered
mechanistic studies of normal and malignant hematopoiesis and the validation of novel …

Somatic mutations in cancer genes have been detected in clonal expansions across healthy
human tissue, including in clonal hematopoiesis. However, because mutated and wild-type …

Intravascular neutrophils and platelets collaborate in maintaining host integrity, but their
interaction can also trigger thrombotic complications. We report here that cooperation …

Myeloid neoplasms with erythroid or megakaryocytic differentiation include pure erythroid
leukemia, myelodysplastic syndrome with erythroid features, and acute megakaryoblastic …

Megakaryocytes (MKs), the platelet progenitor cells, play important roles in hematopoietic
stem cell (HSC) maintenance and immunity. However, it is not known whether these diverse …