Colistin regained global interest as a consequence of the rising prevalence of multidrug-
resistant Gram-negative Enterobacteriaceae. In parallel, colistin-resistant bacteria emerged …

Strains of bacteria resistant to antibiotics, particularly those that are multiresistant, are an
increasing major health care problem around the world. It is now abundantly clear that both …

Polymyxins are well-established antibiotics that have recently regained significant interest
as a consequence of the increasing incidence of infections due to multidrug-resistant Gram …

Antibiotic resistance has become a global public health priority. Polymyxins, a family of
cationic polypeptide antibiotics, act as a final line of refuge against severe infections by …

Polymyxins are important lipopeptide antibiotics that serve as the last-line defense against
multidrug-resistant (MDR) Gram-negative bacterial infections. Worryingly, the clinical utility …

Polymyxins have recently been re-introduced into the therapeutic arsenal to combat
infections caused by multidrug-resistant Gram-negative bacteria. However, the emergence …

The plasmid-located mcr-9 gene, encoding a putative phosphoethanolamine transferase,
was identified in a colistin-resistant human fecal Escherichia coli strain belonging to a very …

Colistin, also referred to as polymyxin E, is an effective antibiotic against most multidrug-
resistant Gram-negative bacteria and is currently used as a last-line drug for treating severe …

In this Leading article, we summarize current knowledge of the occurrence of the first and so
far only transferable colistin resistance gene, mcr-1. Its location on a conjugative plasmid is …

Colistin is considered to be an antimicrobial of last-resort for the treatment of multidrug-
resistant Gram-negative bacterial infections. The recent global dissemination of mobilized …