Abstract Chitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein that mediates
inflammation, macrophage polarization, apoptosis, and carcinogenesis. The expression of …

Abstract Glycoside hydrolase family 18 (GH18) chitinases, which catalyze the
biodegradation of β-1, 4 glycosidic bond in amino polysaccharides via a substrate-assisted …

Myeloproliferative neoplasms (MPNs), encompassing disorders like polycythemia vera (PV),
essential thrombocythemia (ET), and primary myelofibrosis (PMF), are characterized by …

Identification and treatment of abdominal aortic aneurysm (AAA) remain among the most
prominent challenges in vascular medicine. MicroRNAs (miRNAs) are crucial regulators of …

Trimethylamine N-oxide (TMAO) is a circulating metabolite that has been implicated in the
development of atherosclerosis and cardiovascular disease (CVD). In this paper, we identify …

In a search of new bone proteins, the glycoprotein YKL-40 was identified in 1989 to be
secreted in vitro in large amount by the human osteosarcoma cell line MG63. The protein …

YKL-40, a member of the “mammalian chitinase–like proteins,” is expressed and secreted by
several types of solid tumors. The exact function of YKL-40 in cancer diseases is unknown …

Abstract Chitinase 3-like 1 (CHI3L1) is a secreted glycoprotein that mediates inflammation,
macrophage polarization, apoptosis, and carcinogenesis. The expression of CHI3L1 is …

Non-alcoholic fatty liver disease (NAFLD) is an emerging metabolic-related disorder
characterized by fatty infiltration of the liver in the absence of alcohol consumption. NAFLD …

Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder due to the
deficient activity of the acid beta-glucosidase (GCase) enzyme, resulting in the progressive …