The 2019 mathematical oncology roadmap
Whether the nom de guerre is Mathematical Oncology, Computational or Systems Biology,
Theoretical Biology, Evolutionary Oncology, Bioinformatics, or simply Basic Science, there is …
Theoretical Biology, Evolutionary Oncology, Bioinformatics, or simply Basic Science, there is …
The topology of data: opportunities for cancer research
Motivation Topological methods have recently emerged as a reliable and interpretable
framework for extracting information from high-dimensional data, leading to the creation of a …
framework for extracting information from high-dimensional data, leading to the creation of a …
Real-world validity of randomized controlled phase III trials in newly diagnosed glioblastoma: to whom do the results of the trials apply?
E Skaga, MA Skretteberg… - Neuro-Oncology …, 2021 - academic.oup.com
Background The survival rates in population-based series of glioblastoma (GBM) differ
substantially from those reported in clinical trials. This discrepancy may be attributed to that …
substantially from those reported in clinical trials. This discrepancy may be attributed to that …
Clinical features associated with the efficacy of chemotherapy in patients with glioblastoma (GBM): a surveillance, epidemiology, and end results (SEER) analysis
Background Glioblastoma (GBM) is a highly malignant brain tumor with poor survival and
prognosis. Randomized trials have demonstrated that chemotherapy improves survival in …
prognosis. Randomized trials have demonstrated that chemotherapy improves survival in …
MEK inhibitors-novel targeted therapies of neurofibromatosis associated benign and malignant lesions
A Harder - Biomarker Research, 2021 - Springer
Abstract MAP/ERK kinase 1 and 2 (MEK 1/2) inhibitors (MEKi) are investigated in several
trials to treat lesions that arise from pathogenic variants of the Neurofibromatosis type 1 and …
trials to treat lesions that arise from pathogenic variants of the Neurofibromatosis type 1 and …
Tumors diagnosed as cerebellar glioblastoma comprise distinct molecular entities
A Reinhardt, D Stichel, D Schrimpf, C Koelsche… - Acta neuropathologica …, 2019 - Springer
In this multi-institutional study we compiled a retrospective cohort of 86 posterior fossa
tumors having received the diagnosis of cerebellar glioblastoma (cGBM). All tumors were …
tumors having received the diagnosis of cerebellar glioblastoma (cGBM). All tumors were …
TopoAct: Visually exploring the shape of activations in deep learning
Deep neural networks such as GoogLeNet, ResNet, and BERT have achieved impressive
performance in tasks such as image and text classification. To understand how such …
performance in tasks such as image and text classification. To understand how such …
miR-124 regulates early isolation-induced social abnormalities via inhibiting myelinogenesis in the medial prefrontal cortex
Y Zhang, Y Pang, W Feng, Y **, S Chen… - Cellular and Molecular …, 2022 - Springer
Patients with autism spectrum disorder (ASD) typically experience substantial social
isolation, which may cause secondary adverse effects on their brain development. miR-124 …
isolation, which may cause secondary adverse effects on their brain development. miR-124 …
[HTML][HTML] Transcription factors specificity protein and nuclear receptor 4A1 in pancreatic cancer
Specificity protein (Sp) transcription factors (TFs) Sp1, Sp3 and Sp4, and the orphan nuclear
receptor 4A1 (NR4A1) are highly expressed in pancreatic tumors and Sp1 is a negative …
receptor 4A1 (NR4A1) are highly expressed in pancreatic tumors and Sp1 is a negative …
Diffuse gliomas of the brainstem and cerebellum in adults show molecular heterogeneity
KL Eschbacher, CM Ida, DR Johnson… - The American journal …, 2021 - journals.lww.com
Posterior fossa (PF) diffuse gliomas in pediatric patients frequently harbor the H3 K27M
mutation. Among adults, PF diffuse gliomas are rare, with limited data regarding molecular …
mutation. Among adults, PF diffuse gliomas are rare, with limited data regarding molecular …