DNA replication and transcription use the same template and occur concurrently in bacteria.
The lack of temporal and spatial separation of these two processes leads to their conflict …

Transcription, the first step of gene expression, is carried out by the enzyme RNA
polymerase (RNAP) and is regulated through interaction with a series of protein transcription …

The enormous diversity of proteoforms produces tremendous complexity within cellular
proteomes, facilitates intricate networks of molecular interactions, and constitutes a …

To understand living cells, we need knowledge of each of their parts as well as about the
interactions of these parts. To gain rapid and comprehensive access to this information …

Desiccation impacts a suite of physiological processes in microbes by elevating levels of
damaging reactive oxygen species and inducing DNA strand breaks. In response to …

The seven extracytoplasmic function (ECF) sigma (σ) factors of Bacillus subtilis are broadly
implicated in resistance to antibiotics and other cell envelope stressors mediated, in part, by …

The transcriptional regulator Spx plays a key role in maintaining the redox homeostasis of
Bacillus subtilis cells exposed to disulfide stress. Defects in Spx were previously shown to …

In the post-genomic era, most components of a cell are known and they can be quantified by
large-scale functional genomics approaches. However, genome annotation is the bottleneck …

Bacteria have evolved structured RNAs that can associate with RNA polymerase (RNAP).
Two of them have been known so far—6S RNA and Ms1 RNA but it is unclear if any other …

Two bisdihydroanthracenone atropodiastereomeric pairs, including homodimeric
flavomannin A (1) and the previously unreported flavomannin B (2), two new unsymmetrical …