Cancer cachexia: mediators, signaling, and metabolic pathways

KCH Fearon, DJ Glass, DC Guttridge - Cell metabolism, 2012 - cell.com
Cancer cachexia is characterized by a significant reduction in body weight resulting
predominantly from loss of adipose tissue and skeletal muscle. Cachexia causes reduced …

Signaling pathways controlling skeletal muscle mass

MA Egerman, DJ Glass - Critical reviews in biochemistry and …, 2014 - Taylor & Francis
The molecular mechanisms underlying skeletal muscle maintenance involve interplay
between multiple signaling pathways. Under normal physiological conditions, a network of …

[PDF][PDF] Probiotic Lactobacillus rhamnosus GG Prevents Liver Fibrosis Through Inhibiting Hepatic Bile Acid Synthesis and Enhancing Bile Acid Excretion in Mice

Y Liu, K Chen, F Li, Z Gu, Q Liu, L He, T Shao… - …, 2020 - Wiley Online Library
Background and Aims Cholestatic liver disease is characterized by gut dysbiosis and
excessive toxic hepatic bile acids (BAs). Modification of gut microbiota and repression of BA …

Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy

G Milan, V Romanello, F Pescatore, A Armani… - Nature …, 2015 - nature.com
Stresses like low nutrients, systemic inflammation, cancer or infections provoke a catabolic
state characterized by enhanced muscle proteolysis and amino acid release to sustain liver …

RING domain E3 ubiquitin ligases

RJ Deshaies, CAP Joazeiro - Annual review of biochemistry, 2009 - annualreviews.org
E3 ligases confer specificity to ubiquitination by recognizing target substrates and mediating
transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate. The activity of …

Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human

C Widmann, S Gibson, MB Jarpe… - Physiological …, 1999 - journals.physiology.org
Widmann, Christian, Spencer Gibson, Matthew B. Jarpe, and Gary L. Johnson. Mitogen-
Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human …

A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase

XJ Song, W Huang, M Shi, MZ Zhu, HX Lin - Nature genetics, 2007 - nature.com
Grain weight is one of the most important components of grain yield and is controlled by
quantitative trait loci (QTLs) derived from natural variations in crops. However, the molecular …

Skeletal muscle hypertrophy and atrophy signaling pathways

DJ Glass - The international journal of biochemistry & cell biology, 2005 - Elsevier
Skeletal muscle hypertrophy is defined as an increase in muscle mass, which in the adult
animal comes as a result of an increase in the size, as opposed to the number, of pre …

RBR E3 ubiquitin ligases: new structures, new insights, new questions

DE Spratt, H Walden, GS Shaw - Biochemical journal, 2014 - portlandpress.com
The RBR (RING-BetweenRING-RING) or TRIAD [two RING fingers and a DRIL (double
RING finger linked)] E3 ubiquitin ligases comprise a group of 12 complex multidomain …

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

S Fang, JP Jensen, RL Ludwig, KH Vousden… - Journal of Biological …, 2000 - ASBMB
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal
degradation. We now report that Mdm2 is a ubiquitin protein ligase (E3) for p53 and that its …