Cancer cachexia is characterized by a significant reduction in body weight resulting
predominantly from loss of adipose tissue and skeletal muscle. Cachexia causes reduced …

The molecular mechanisms underlying skeletal muscle maintenance involve interplay
between multiple signaling pathways. Under normal physiological conditions, a network of …

Stresses like low nutrients, systemic inflammation, cancer or infections provoke a catabolic
state characterized by enhanced muscle proteolysis and amino acid release to sustain liver …

E3 ligases confer specificity to ubiquitination by recognizing target substrates and mediating
transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate. The activity of …

Widmann, Christian, Spencer Gibson, Matthew B. Jarpe, and Gary L. Johnson. Mitogen-
Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human …

Grain weight is one of the most important components of grain yield and is controlled by
quantitative trait loci (QTLs) derived from natural variations in crops. However, the molecular …

Skeletal muscle hypertrophy is defined as an increase in muscle mass, which in the adult
animal comes as a result of an increase in the size, as opposed to the number, of pre …

The RBR (RING-BetweenRING-RING) or TRIAD [two RING fingers and a DRIL (double
RING finger linked)] E3 ubiquitin ligases comprise a group of 12 complex multidomain …

Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal
degradation. We now report that Mdm2 is a ubiquitin protein ligase (E3) for p53 and that its …

SUMMARY A cascade of three protein kinases known as a mitogen-activated protein kinase
(MAPK) cascade is commonly found as part of the signaling pathways in eukaryotic cells …