Cardiovascular Diseases (CVDs) are the leading cause of death globally. More than 17
million people die worldwide from CVD per year. There is considerable evidence suggesting …

Pulmonary hypertension (PH) encompasses a syndrome of diseases that are characterized
by elevated pulmonary artery pressure and pulmonary vascular remodeling and that …

The low-density lipoprotein receptor (LDLR) gene family includes LDLR, very LDLR, and
LDL receptor–related proteins (LRPs) such as LRP1, LRP1b (aka LRP-DIT), LRP2 (aka …

Pulmonary arterial hypertension (PAH) is a debilitating and progressive disease that
predominantly develops in women. Over the past 15 years, cumulating evidence has …

Purpose The underlying causes of pulmonary arterial hypertension (PAH) often remain
obscure. Addressing PAH with effective treatments presents a formidable challenge. Studies …

Objectives To investigate the effects of geniposide in an iridoid found in Gardenia
jasminoides var. radicans Makino (GJRM) in spontaneous hypertensive rat (SHR) and …

BACKGROUND: Apolipoprotein (apo) E isoforms have strong correlations with metabolic
and cardiovascular diseases. However, it is not clear if apoE has a role in development of …

ApoE abnormality represents a well-known risk factor for cardiovascular diseases. Beyond
its role in lipid metabolism, novel studies demonstrate a complex involvement of apoE in …

Pulmonary arterial hypertension (PAH), a debilitating and incurable disease, predominantly
develops in women. Estradiol metabolism leads to the production of numerous metabolites …

Animal models that mimic key features of the transition from right ventricular (RV) adaptation
towards decompensation and RV failure in the context of pulmonary hypertension are …