Intranasal delivery of mesenchymal stem cells-derived extracellular vesicles for the treatment of neurological diseases

S Herman, I Fishel, D Offen - Stem Cells, 2021 - academic.oup.com
Neurological disorders are diseases of the central nervous system (CNS), characterized by
a progressive degeneration of cells and deficiencies in neural functions. Mesenchymal stem …

Mesenchymal stromal cells (MSCs) for neurodegenerative disease: a promising frontier

A Shariati, R Nemati, Y Sadeghipour… - European journal of cell …, 2020 - Elsevier
Neurodegenerative disorders are a variety of diseases including Alzheimer's (AD),
Parkinson's (PD), and Huntington's diseases (HD), multiple sclerosis (MS) and amyotrophic …

Targeted Delivery of RGD-CD146+CD271+ Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Promotes Blood–Spinal Cord Barrier Repair after …

Y **e, Y Sun, Y Liu, J Zhao, Q Liu, J Xu, Y Qin, R He… - ACS …, 2023 - ACS Publications
Spinal cord injury (SCI) disrupts the blood–spinal cord barrier (BSCB), potentially
exacerbating nerve damage and emphasizing the criticality of preserving the BSCB integrity …

Extracellular vesicles from mesenchymal stem cells: towards novel therapeutic strategies for neurodegenerative diseases

E Turano, I Scambi, F Virla, B Bonetti… - International Journal of …, 2023 - mdpi.com
Neurodegenerative diseases are fatal disorders of the central nervous system (CNS) which
currently lack effective treatments. The application of mesenchymal stem cells (MSCs) …

Intranasal delivery of small extracellular vesicles from specific subpopulation of mesenchymal stem cells mitigates traumatic spinal cord injury

Y Sun, J Zhao, Q Liu, Y Xu, Y Qin, R He, L Zheng… - Journal of Controlled …, 2024 - Elsevier
Vascular injury following spinal cord injury (SCI) can significantly exacerbate secondary SCI
and result in neurological dysfunction. Strategies targeting angiogenesis have demonstrated …

[HTML][HTML] Nanomodulation of macrophages in multiple sclerosis

FK Nally, C De Santi, CE McCoy - Cells, 2019 - mdpi.com
Multiple Sclerosis (MS) is a chronic demyelinating autoimmune disease primarily affecting
young adults. Despite an unclear causal factor, symptoms and pathology arise from the …

Intranasal administration of small extracellular vesicles derived from mesenchymal stem cells ameliorated the experimental autoimmune encephalomyelitis

A Fathollahi, SM Hashemi, MHM Hoseini… - International …, 2021 - Elsevier
Experimental autoimmune encephalomyelitis (EAE) is a mouse model for the human
multiple sclerosis, which is characterized by inflammation in the central nervous system …

Immunomodulatory characteristics of mesenchymal stem cells and their role in the treatment of multiple sclerosis

T Gharibi, M Ahmadi, N Seyfizadeh, F Jadidi-Niaragh… - Cellular …, 2015 - Elsevier
Multiple Sclerosis (MS) is a chronic inflammatory neurodegenerative disease of central
nervous system (CNS). Although the main cause of MS is not clear, studies suggest that MS …

[HTML][HTML] New idea to promote the clinical applications of stem cells or their extracellular vesicles in central nervous system disorders: Combining with intranasal …

Y Li, H Wu, X Jiang, Y Dong, J Zheng, J Gao - Acta Pharmaceutica Sinica B, 2022 - Elsevier
The clinical translation of stem cells and their extracellular vesicles (EVs)-based therapy for
central nervous system (CNS) diseases is booming. Nevertheless, the insufficient CNS …

Intranasal drug delivery: A non-invasive approach for the better delivery of neurotherapeutics

H Kumar, G Mishra, AK Sharma… - Pharmaceutical …, 2017 - ingentaconnect.com
Background: The convoluted pathophysiology of brain disorders along with penetration
issue of drugs to brain represents major hurdle that requires some novel therapies. The …