Cyanine dyes derived inhibition of insulin fibrillization

K Vus, M Girych, V Trusova, G Gorbenko… - Journal of Molecular …, 2019 - Elsevier
The potential of novel cyanine dyes to inhibit the insulin amyloid formation was evaluated
using thioflavin T fluorescence assay, quantum-chemical calculations, molecular docking …

Study of anti-fibrillogenic activity of iron (II) clathrochelates

VB Kovalska, MY Losytskyy, OA Varzatskii… - Bioorganic & Medicinal …, 2014 - Elsevier
The macrocyclic compounds mono-and bis-iron (II) clathrochelates were firstly studied as
potential anti-fibrillogenic agents using fluorescent inhibitory assay, atomic force microscopy …

Aggregation behavior of novel heptamethine cyanine dyes upon their binding to native and fibrillar lysozyme

K Vus, U Tarabara, A Kurutos, O Ryzhova… - Molecular …, 2017 - pubs.rsc.org
Two newly synthesized symmetrical heptamethine cyanine dyes, AK7-5 and AK7-6,
absorbing in the region of low autofluorescence of biological samples, have been tested for …

Probing the amyloid protein aggregates with unsymmetrical monocationic trimethine cyanine dyes

O Zhytniakivska, A Kurutos, U Tarabara, K Vus… - Journal of Molecular …, 2020 - Elsevier
A series of novel trimethine cyanine dyes were synthesized and evaluated as potential
probes for the detection of pathogenic protein aggregates, amyloid fibrils. The spectral …

New photosensitive nanometric graphite oxide composites as antimicrobial material with prolonged action

Y Gerasymchuk, A Lukowiak, A Wedzynska… - Journal of Inorganic …, 2016 - Elsevier
A new conjugate material based on partially reduced graphite oxide (rGO), silver
nanoparticles (Ag), and bis (lysinato) zirconium (IV) phthalocyanine complex (ZrPc) was …

The impact of binding of macrocyclic metal complexes on amyloid fibrillization of insulin and lysozyme

V Kovalska, S Chernii, V Cherepanov… - Journal of Molecular …, 2017 - Wiley Online Library
Amyloid fibrils are insoluble protein aggregates whose accumulation in cells and tissues is
connected with a range of pathological diseases. We studied the impact of 2 metal …

Trimethine cyanine dyes as fluorescent probes for amyloid fibrils: The effect of N, N′-substituents

MV Kuperman, SV Chernii, MY Losytskyy… - Analytical …, 2015 - Elsevier
The effect of various N, N′-substituents in the molecule of benzothiazole trimethine cyanine
dye on its ability to sense the amyloid aggregates of protein was studied. The dyes are low …

β-ketoenole dyes: Synthesis and study as fluorescent sensors for protein amyloid aggregates

V Kovalska, S Chernii, M Losytskyy, Y Dovbii… - Dyes and …, 2016 - Elsevier
The series of the β-ketoenoles (2E, 5Z, 7E, 9E)-2-(alkylamino)-6-hydroxy-10-phenyldeca-2,
5, 7, 9-tetraen-4-ones with variation of the alkylamino tail groups was synthesized and …

Anti-fibrillogenic properties of phthalocyanines: Effect of the out-of-plane ligands

V Kovalska, V Cherepanov, M Losytskyy… - Bioorganic & Medicinal …, 2014 - Elsevier
The axially-coordinated phthalocyanines were previously reported as agents possessing
strong anti-fibrillogenic properties. In the presented study we used the atomic force …

Synthesis, spectroscopic, and biological studies on new zirconium (IV) porphyrins with axial ligand

GD Bajju, G Devi, S Katoch, M Bhagat… - Bioinorganic …, 2013 - Wiley Online Library
A series of parasubstituted tetraphenylporphyrin zirconium (IV) salicylate complexes (SA/5‐
SSAZr (IV) RTPP, R= p‐H, p‐CH3, p‐NO2, p‐Cl, SA= salicylate, and 5‐SSA= 5 …