During the last two decades our understanding of human B cell differentiation has
developed considerably. Our understanding of the human B cell compartment has advanced …

Streptococcus pneumoniae (S. pneumoniae, pneumococcus) is a major cause of morbidity
and mortality worldwide. Achieving long-term immunity against S. pneumoniae through …

Human Ab-secreting cell (ASC) populations in circulation are not well studied. In addition to
B-1 (CD20+ CD27+ CD38 lo/int CD43+) cell and conventional plasmablast (PB)(CD20 …

Background Chronic lymphocytic leukemia (CLL) leads to significant immune system
dysfunction. The predominant clinical presentation in 50% of patients involves recurrent …

Inflammatory bowel disease (IBD) is an immunological disorder that is usually treated with
immunosuppressive therapy, potentially leading to increases in vulnerability to infections …

Natural antibodies are spontaneously produced in the absence of infection or immunization,
and are both anti-microbial and autoreactive. Autoreactive natural antibodies can bind …

In recent years, in addition to the well-established role of T cells in controlling or promoting
tumor growth, a new wave of research has demonstrated the active involvement of B cells in …

Only few studies have described the anti-tumor properties of natural antibodies (NAbs). In
particular, natural IgM have been linked to cancer immunosurveillance due to its preferential …

The B-1 B cell population is an important bridge between innate and adaptive immunity
primarily because B-1 cells produce natural Ab. Murine B-1 and B-2 cells arise from distinct …

B‐1 cells represent a subpopulation of B cells that has been extensively studied in mice and
shown to spontaneously generate natural antibody that provides antimicrobial protection …