Tau and neurodegenerative disease: the story so far
In 1975, tau protein was isolated as a microtubule-associated factor from the porcine brain.
In the previous year, a paired helical filament (PHF) protein had been identified in …
In the previous year, a paired helical filament (PHF) protein had been identified in …
Targeting the synapse in Alzheimer's disease
J Jackson, E Jambrina, J Li, H Marston… - Frontiers in …, 2019 - frontiersin.org
Dynamic gain and loss of synapses is fundamental to healthy brain function. While
Alzheimer's Disease (AD) treatment strategies have largely focussed on beta-amyloid and …
Alzheimer's Disease (AD) treatment strategies have largely focussed on beta-amyloid and …
Factors that influence adult neurogenesis as potential therapy
Adult neurogenesis involves persistent proliferative neuroprogenitor populations that reside
within distinct regions of the brain. This phenomenon was first described over 50 years ago …
within distinct regions of the brain. This phenomenon was first described over 50 years ago …
Innovative therapy for Alzheimer's disease-with focus on biodelivery of NGF
Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with
abnormal protein modification, inflammation and memory impairment. Aggregated amyloid …
abnormal protein modification, inflammation and memory impairment. Aggregated amyloid …
Aging with alcohol-related brain damage: Critical brain circuits associated with cognitive dysfunction
Alcoholism is associated with brain damage and impaired cognitive functioning. The relative
contributions of different etiological factors, such as alcohol, thiamine deficiency and age …
contributions of different etiological factors, such as alcohol, thiamine deficiency and age …
Neurotrophic factor small-molecule mimetics mediated neuroregeneration and synaptic repair: emerging therapeutic modality for Alzheimer's disease
SF Kazim, K Iqbal - Molecular neurodegeneration, 2016 - Springer
Alzheimer's disease (AD) is an incurable and debilitating chronic progressive
neurodegenerative disorder which is the leading cause of dementia worldwide. AD is a …
neurodegenerative disorder which is the leading cause of dementia worldwide. AD is a …
Exercise as a pro-cognitive, pro-neurogenic and anti-inflammatory intervention in transgenic mouse models of Alzheimer's disease
SM Ryan, ÁM Kelly - Ageing research reviews, 2016 - Elsevier
It is now well established, at least in animal models, that exercise elicits potent pro-cognitive
and pro-neurogenic effects. Alzheimer's disease (AD) is one of the leading causes of …
and pro-neurogenic effects. Alzheimer's disease (AD) is one of the leading causes of …
[HTML][HTML] Taurine increases hippocampal neurogenesis in aging mice
E Gebara, F Udry, S Sultan, N Toni - Stem cell research, 2015 - Elsevier
Aging is associated with increased inflammation and reduced hippocampal neurogenesis,
which may in turn contribute to cognitive impairment. Taurine is a free amino acid found in …
which may in turn contribute to cognitive impairment. Taurine is a free amino acid found in …
[HTML][HTML] Therapeutic strategies aimed at improving neuroplasticity in Alzheimer disease
MF Colavitta, FJ Barrantes - Pharmaceutics, 2023 - mdpi.com
Alzheimer disease (AD) is the most prevalent form of dementia among elderly people.
Owing to its varied and multicausal etiopathology, intervention strategies have been highly …
Owing to its varied and multicausal etiopathology, intervention strategies have been highly …
Born to protect: leveraging BDNF against cognitive deficit in Alzheimer's disease
Alzheimer's disease is a chronic neurodegenerative devastating disorder affecting a high
percentage of the population over 65 years of age and causing a relevant emotional, social …
percentage of the population over 65 years of age and causing a relevant emotional, social …