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Myokit: a simple interface to cardiac cellular electrophysiology
Myokit is a new powerful and versatile software tool for modeling and simulation of cardiac
cellular electrophysiology. Myokit consists of an easy-to-read modeling language, a …
cellular electrophysiology. Myokit consists of an easy-to-read modeling language, a …
3D virtual human atria: A computational platform for studying clinical atrial fibrillation
Despite a vast amount of experimental and clinical data on the underlying ionic, cellular and
tissue substrates, the mechanisms of common atrial arrhythmias (such as atrial fibrillation …
tissue substrates, the mechanisms of common atrial arrhythmias (such as atrial fibrillation …
How the Hodgkin–Huxley equations inspired the cardiac physiome project
Early modelling of cardiac cells (1960–1980) was based on extensions of the Hodgkin–
Huxley nerve axon equations with additional channels incorporated, but after 1980 it …
Huxley nerve axon equations with additional channels incorporated, but after 1980 it …
Pro‐arrhythmogenic effects of atrial fibrillation‐induced electrical remodelling: insights from the three‐dimensional virtual human atria
Key points• Previous studies have shown that atrial electrical properties are altered
(remodelled) by atrial fibrillation (AF) and that the recurrence of AF is high following …
(remodelled) by atrial fibrillation (AF) and that the recurrence of AF is high following …
Application of micro-computed tomography with iodine staining to cardiac imaging, segmentation, and computational model development
Micro-computed tomography (micro-CT) has been widely used to generate high-resolution 3-
D tissue images from small animals nondestructively, especially for mineralized skeletal …
D tissue images from small animals nondestructively, especially for mineralized skeletal …
Four ways to fit an ion channel model
Mathematical models of ionic currents are used to study the electrophysiology of the heart,
brain, gut, and several other organs. Increasingly, these models are being used predictively …
brain, gut, and several other organs. Increasingly, these models are being used predictively …
Application of cardiac electrophysiology simulations to pro‐arrhythmic safety testing
Concerns over cardiac side effects are the largest single cause of compound attrition during
pharmaceutical drug development. For a number of years, biophysically detailed …
pharmaceutical drug development. For a number of years, biophysically detailed …
[HTML][HTML] Recent developments in using mechanistic cardiac modelling for drug safety evaluation
Highlights•Modelling and simulation can streamline decision making in drug safety
testing.•Computational cardiac electrophysiology is a mature technology with a long …
testing.•Computational cardiac electrophysiology is a mature technology with a long …
Species-dependent mechanisms of cardiac arrhythmia: a cellular focus
Although ventricular arrhythmia remains a leading cause of morbidity and mortality,
available antiarrhythmic drugs have limited efficacy. Disappointing progress in the …
available antiarrhythmic drugs have limited efficacy. Disappointing progress in the …
High-throughput screening of drug-binding dynamics to HERG improves early drug safety assessment
The use of computational models to predict drug-induced changes in the action potential
(AP) is a promising approach to reduce drug safety attrition but requires a better …
(AP) is a promising approach to reduce drug safety attrition but requires a better …