Unravelling the enigma of siRNA and aptamer mediated therapies against pancreatic cancer

Z Liu, N Parveen, U Rehman, A Aziz, A Sheikh… - Molecular Cancer, 2023 - Springer
Pancreatic cancer (PC) is a fatal disease that has a poor 5-year survival rate. The poor
prognosis can be attributed to both troublesome detections at the initial stage, which makes …

[HTML][HTML] Liposome-based diagnostic and therapeutic applications for pancreatic cancer

F Raza, L Evans, M Motallebi, H Zafar, M Pereira-Silva… - Acta Biomaterialia, 2023 - Elsevier
Pancreatic cancer is one of the harshest and most challenging cancers to treat, often labeled
as incurable. Chemotherapy continues to be the most popular treatment yet yields a very …

Polymeric micelles assisted combinatorial therapy: Is it new hope for pancreatic cancer?

U Rehman, MAS Abourehab, A Alexander… - European Polymer …, 2023 - Elsevier
Pancreatic cancer (PC) is a fatal disease that has a 5-year survival rate of less than 9%. It is
expected to rank second in cancer-related deaths across the United States by 2030. Out of …

Targeted therapies for pancreatic cancer and hurdles ahead

M Aslan, R Shahbazi, K Ulubayram… - Anticancer …, 2018 - ar.iiarjournals.org
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal cancers
with a median survival of 6 months after diagnosis. Intrinsic resistance to chemotherapeutics …

[HTML][HTML] Dendrimer-based nanocomposites for the production of RNA delivery systems

CC Lim, LY Chia, PV Kumar - OpenNano, 2023 - Elsevier
A novel approach to treating cancer has been revealed to be effective cancer vaccination. It
has also been demonstrated that nucleic acid therapies such as mRNA and siRNA are very …

Nucleic acid nanotechnology for cancer treatment

JO **, G Kim, J Hwang, KH Han, M Kwak… - Biochimica et Biophysica …, 2020 - Elsevier
Cancer is one of the most prevalent potentially lethal diseases. With the increase in the
number of investigations into the uses of nanotechnology, many nucleic acid (NA)-based …

Tailor‐made nanomaterials for diagnosis and therapy of pancreatic ductal adenocarcinoma

X Hu, F **a, J Lee, F Li, X Lu, X Zhuo, G Nie… - Advanced …, 2021 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers worldwide due to
its aggressiveness and the challenge to early diagnosis and treatment. In recent decades …

Current status of biomarker and targeted nanoparticle development: The precision oncology approach for pancreatic cancer therapy

L Zhu, C Staley, D Kooby, B El-Rays, H Mao, L Yang - Cancer letters, 2017 - Elsevier
Pancreatic cancer remains one of the major causes of cancer-related mortality. The majority
of pancreatic cancer patients are diagnosed at the advanced stage with unresectable and …

Neuroblastoma: oncogenic mechanisms and therapeutic exploitation of necroptosis

S Nicolai, M Pieraccioli, A Peschiaroli, G Melino… - Cell death & …, 2015 - nature.com
Neuroblastoma (NB) is the most common extracranial childhood tumor classified in five
stages (1, 2, 3, 4 and 4S), two of which (3 and 4) identify chemotherapy-resistant, highly …

Nonviral siRNA delivery systems for pancreatic cancer therapy

S Aghamiri, P Raee, S Talaei… - Biotechnology and …, 2021 - Wiley Online Library
The serious drawbacks of the conventional treatment of pancreatic ductal adenocarcinoma
(PDAC) such as nonspecific toxicity and high resistance to chemo and radiation therapy …