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PROTAC degraders with ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective
Mouse double minute 2 (MDM2) is an E3 ubiquitin ligase which effectively degrades tumor
suppressor p53. In the past two decades, many MDM2 inhibitors that disrupt the MDM2-p53 …
suppressor p53. In the past two decades, many MDM2 inhibitors that disrupt the MDM2-p53 …
[HTML][HTML] Role of PARP inhibitors in cancer immunotherapy: potential friends to immune activating molecules and foes to immune checkpoints
O Franzese, G Graziani - Cancers, 2022 - mdpi.com
Simple Summary This review aims at analyzing an emergent topic regarding the possible
combined use of poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi), anticancer drugs …
combined use of poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi), anticancer drugs …
DNA methylation malleability and dysregulation in cancer progression: Understanding the role of PARP1
Mammalian genomic DNA methylation represents a key epigenetic modification and its
dynamic regulation that fine-tunes the gene expression of multiple pathways during …
dynamic regulation that fine-tunes the gene expression of multiple pathways during …
Multi-omics strategy reveals that Cordyceps sinensis ameliorates sepsis-associated acute kidney injury via reprogramming of mitochondrial energy metabolism and …
L Chen, T Yang, J Wu, G Cheng, M Zhao… - Acta Materia …, 2024 - scienceopen.com
Cordyceps sinensis (CS) has been widely used as a dietary supplement or traditional
medicine for the prevention, treatment, and prognostication of various diseases, because of …
medicine for the prevention, treatment, and prognostication of various diseases, because of …
High matrix stiffness accelerates migration of hepatocellular carcinoma cells through the integrin β1-Plectin-F-actin axis
Z Wang, W Wang, Q Luo, G Song - BMC biology, 2025 - Springer
Background Abundant research indicates that increased extracellular matrix (ECM) stiffness
significantly enhances the malignant characteristics of hepatocellular carcinoma (HCC) …
significantly enhances the malignant characteristics of hepatocellular carcinoma (HCC) …
HKDC1 promotes autophagy and proliferation in pancreatic adenocarcinoma through interaction with PARP1 and poly (ADP-ribosyl) ation
Q Pang, S Huang, H Wang, J Cao - Cellular Signalling, 2024 - Elsevier
Background HKDC1 has been shown to play an important role in promoting malignant
progression of pancreatic adenocarcinoma (PAAD), but the exact mechanism is unclear …
progression of pancreatic adenocarcinoma (PAAD), but the exact mechanism is unclear …
[HTML][HTML] Advances in non-apoptotic regulated cell death: implications for malignant tumor treatment
Y Zhang, S Yi, M Luan - Frontiers in Oncology, 2025 - pmc.ncbi.nlm.nih.gov
Cell death mechanisms are broadly classified into accidental cell death (ACD) and
regulated cell death (RCD). ACD such as necrosis, is an uncontrolled, accidental process …
regulated cell death (RCD). ACD such as necrosis, is an uncontrolled, accidental process …